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ABE70 | Anti-BAF180 Antibody

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, M WB, ChIP Rb Purified Polyclonal Antibody
      Catalogue NumberABE70
      DescriptionAnti-BAF180 Antibody
      Alternate Names
      • polybromo 1
      • protein polybromo-1
      • BRG1-associated factor 180
      • polybromo-1D
      • Polybromo-1D
      Background InformationBRG1-associated factor 180 (BAF180) is a subunit of the SWI/SNF-B (PBAF) chromatin remodeling complex, and is known to contain 6 bromo domains, 2 BAH domains, and a single HMG box DNA-binding domain. BAF180 has a critical and active role in the transcriptional activation and repression of specific genes via chromatin remodeling, including genes involved in the development of the heart, thus suggesting a role in mammalian development. Recent studies demonstrate BAF180 to suppress tumorigenesis through its ability to regulate both baseline and signal-dependent p21 transcription by its binding of the p21 promoter. Expression of BAF180 is reported in a wide range of tissues.
      Product Information
      • HEK293 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-BAF180 Antibody is a Rabbit Polyclonal Antibody for detection of BAF180 also known as protein polybromo-1, BRG1-associated factor 180 & has been validated in WB.
      Key Applications
      • Western Blotting
      • Chromatin Immunoprecipitation (ChIP)
      Application NotesChromatin Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in ChIP (Xia, W., et al. (2008).
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human BAF180.
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PB1
      • BAF180
      • PBRM1
      • hPB1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).

      SUBUNIT STRUCTURE: Component of the SWI/SNF-B (PBAF) chromatin-remodeling complex, which contains at least SMARCA4/BRG1, SMARCB1/SNF5/INI1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Interacts with PHF10/BAF45A (By similarity).


      TISSUE SPECIFICTY: Widely expressed.

      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

      SEQUENCE SIMILARITIES: Contains 2 BAH domains.

      Contains 6 bromo domains.

      Contains 1 HMG box DNA-binding domain.

      SEQUENCE CAUTION: The sequence AAI15010.1 differs from that shown. Reason: Contaminating sequence.

      The sequence AAI15011.1 differs from that shown. Reason: Erroneous initiation.

      The sequence AAI15012.1 differs from that shown. Reason: Erroneous termination at position 78. Translated as Arg.

      The sequence BAB71210.1 differs from that shown. Reason: Erroneous initiation.
      Molecular Weight~193 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HEK293 cell lysate.

      Western Blot Analysis: A 1:1,000 dilution of this antibody detected BAF180 in 10 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-BAF180 2480858
      Anti-BAF180 2475906
      Anti-BAF180 - 2026419 2026419
      Anti-BAF180 - 2207223 2207223
      Anti-BAF180 - 2303969 2303969
      Anti-BAF180 - NG1940985 NG1940985
      Anti-BAF180 - NRG1786880 NRG1786880
      Anti-BAF180 -2562082 2562082
      Anti-BAF180 -2568135 2568135
      Anti-BAF180 -2621967 2621967
      Anti-BAF180 -2688590 2688590
      Anti-BAF180 -2736545 2736545


      Reference overviewPub Med ID
      An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.
      Daxinger, L; Harten, SK; Oey, H; Epp, T; Isbel, L; Huang, E; Whitelaw, N; Apedaile, A; Sorolla, A; Yong, J; Bharti, V; Sutton, J; Ashe, A; Pang, Z; Wallace, N; Gerhardt, DJ; Blewitt, ME; Jeddeloh, JA; Whitelaw, E
      Genome biology 14 R96 2013

      Show Abstract
      24025402 24025402
      E2F6 associates with BRG1 in transcriptional regulation.
      Leung, JY; Nevins, JR
      PloS one 7 e47967 2012

      Show Abstract
      23082233 23082233