A part of MilliporeSigma

ABT251 | Anti-Arpin Antibody

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB, ICC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABT251
      DescriptionAnti-Arpin Antibody
      Alternate Names
      • Arp2/3 inhibition protein
      • Arpin
      Background InformationArpin (UniProt Q7Z6K5; also known as Arp2/3 inhibition protein, UPF0552 protein C15orf38) is encoded by the ARPIN (also known as C15orf38) gene (Gene ID 348110) in human. Cell migration requires the generation of branched actin networks that power the protrusion of the plasma membrane in lamellipodia. The actin-related proteins 2 and 3 (Arp2/3) complex nucleates actin filaments by binding to the side of an existing filament and initiating branch formation. Arpin functions as a negative regulator of Arp2/3 activity, allowing cells to control directional persistence of migration by fine-tuning actin nucleation activity at the leading edge of the lamellipodium. Arpin depletion in both mammalian cells and Dictyostelium discoideum amoeba is reported to result in straighter trajectories. Arpin microinjection is demonstrated to induce fish keratocytes to turn.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-Arpin Antibody is validated for use in Western Blotting, Immunocytochemistry for the detection of Arpin.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:1,000 dilution from a representative lot detected detected Arpin and C15orf38-AP3S2 in MEF-1 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Arpin near the C-terminus.
      Epitopenear Arpin C-terminus
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityReacts with both Arpin and the C15orf38-AP3S2 fusion (isoform 2) produced from a naturally occurring readthrough transcript.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse. Predicted to react with Rat, Chimpanzee, Canine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ARPIN
      • C15orf38
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~28/42 kDa observed (24.9 kDa/Arpin and 43.9 kDa/C15orf38-AP3S2 calculated)
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in MEF-1 murine embryonic fibroblasts cell lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected detected Arpin and C15orf38-AP3S2 in 10 µg of human U2OS and murine MEF-1 embryonic fibroblasts cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information