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MABC164 | Anti-Arl1 Antibody, clone 11A12.1

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ICC M Purified Monoclonal Antibody
      Catalogue NumberMABC164
      DescriptionAnti-Arl1 Antibody, clone 11A12.1
      Alternate Names
      • ADP-ribosylation factor-like protein 1
      Background InformationThe protein named Arl1 or ADP-ribosylation factor-like 1 protein and encoded by the gene ARL1, is a member ADP-ribosylation factor like family that plays an important role in Golgi function and maintenance. The small G protein Arf1 regulates Golgi traffic and is activated by two related types of guanine nucleotide exchange factors (GEFs). GBF1 acts at the cis-Golgi, whereas BIG1 and its close paralog BIG2 act at the trans-Golgi membranes, both work to activate Arl1. Arl1’s GTP-bound form interacts with GOLGA1. The GTP-bound form also interacts with GOLGA4 and RGPD8 and directly interacts with ARFIP2; this interaction leads to a > 4-fold increase in the amount of bound GTP at steady state level, and ARL1 binds to SCOC, preferentially in its GTP-bound form. Arl1 is localized to the Golgi apparatus membrane, the cytoplasmic side. Arl1 is expressed in heart, liver, lung, kidney, placenta, pancreas and skeletal muscle tissues.
      Product Information
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect ADP-ribosylation factor-like 1 protein using this mouse monoclonal antibody, Anti-Arl1 Antibody, clone 11A12.1 validated for use in western blotting & ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:50-250 dilution from a representative lot detected Arl1 in HeLa and MCF-7 cells.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Arl1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ARL1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~19 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEp-2 cell lysate.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected Arl1 in 10 µg of HEp-2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information