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ABS535 | Anti-Arginase-1 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, R, Gp, H WB, IHC Ch Purified Polyclonal Antibody
      Catalogue NumberABS535
      DescriptionAnti-Arginase-1 Antibody
      Alternate Names
      • Type 1 Arginase
      Background InformationArginase-1, the protein encoded by the ARG1 gene, is the enzyme that catalyzes the breakdown of L-arginine into ornithine and urea. ARG1 is a key player in the Urea cycle. There are two distinct isoforms of Arginase, Arginase I and Arginase II. Arginase I (also called the liver type arginase or Type 1 arginase) is a highly expressed cytosolic enzyme in the liver and other tissues, including the brain. Arginase II or kidney-type arginase is also widely expressed at low levels in many tissues but localized to the mitochondria primarily. Interestingly, Arginase 1 has neuroprotective properties. Arginase I is essential for protecting motor neurons from nitric oxide dependent apoptosis that can be induced upon cellular stress or trophic factor removal. By suppressing nitric oxide production, Arginase prevents the formation of peroxynitrite and its subsequent cellular toxicity. Furthermore, Arginase 1 appears to play critical roles throughout the CNS for survival and regeneration of neurons and axons. In cancer, Arginase 1, already a useful marker for hepatocytes is also an excellent marker for hepatocellular cancers.
      Product Information
      PresentationPurified chicken Polyclonal other in buffer containing PBS with 0.05% sodium azide.
      ApplicationThis Anti-Arginase-1 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Arginase-1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A representative lot detected Arginase-1 in bronchoalveolar lavage cells (Zimmermann, N., et al. (2003). J. Clin. Invest. 111:1863–1874 (2003)).
      Western Blotting Analysis: A representative lot detected Arginase-1 in RAW cell lysate (Morris, S., et al. (1998). Am J Physiol Endocrinol Metab 275:E740-E747, 1998).
      Biological Information
      ImmunogenFull-length recombinant protein corresponding to Rat Arginase-1.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Mouse
      • Rat
      • Guinea Pig
      • Human
      Species Reactivity NoteMouse, Rat, Guinea Pig, Human.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ARG1
      Purification MethodIgY purified from Yolk
      UniProt Number
      Molecular Weight~ 38 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse LN tissue lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected Arginase-1 in 10 µg of mouse LN tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information