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AB3076 | Anti-Aquaporin 7 Antibody

50 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R ELISA, ICC, IHC, WB Ch Affinity Purified Polyclonal Antibody
      Catalogue NumberAB3076
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Aquaporin 7 Antibody
      Alternate Names
      • AQP7
      Product Information
      FormatAffinity Purified
      PresentationLiquid in 100 mM Tris, pH 7.5 containing 0.2% BSA as stabilizer and 0.05% sodium azide.
      ApplicationThis Anti-Aquaporin 7 Antibody is validated for use in ELISA, IC, IH, WB for the detection of Aquaporin 7.
      Key Applications
      • ELISA
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL using Chemiluminescence technique

      Immunohistochemistry: We recommend using the affinity purified antibody at 2-10 μg/mL in paraformaldehyde fixed sections of tissues.

      Immunocytochemistry: 2-10 μg/mL. Adherent cells can be fixed in 50% methanol-50% acetone or 1% paraformaldehyde.

      ELISA: 1:100,000 using 50-100 ng of control peptide per well.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenAn 18 AA synthetic peptide within the N-terminal domain of rat Aquaporin-7 (Ishibashi et al. 1997) was selected for antibody production. This domain is predicted to be cytoplasmic.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityWater is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein "aquaporin". Over the last decade, genes for several members of aquaporin family have been cloned, expressed, and their distribution studied in many tissues. Aquaporin-0 or MIP26 (major intrinsic protein 26 kDa), and Aquaporin-1 (purified from red cells) also called CHIP-28 (channel forming integral protein, 28 kDa; 268 AA; gene locus 7p14) has been the foundation of the growing family of aquaporins. The lens specific Aquaporin-0 represents up to 80% of total lens membrane protein. Defects in MIP26 are a cause of autosomal dominant cataract. The cataract Fraser mutation (CAT-FR or Shriveled) is a transposon-induced splicing error that substitutes a long terminal repeat sequence for the c-terminus of MIP. The lens opacity mutation (LOP) is an AA substitution that inhibits targeting of MIP to the cell membrane. Aquaporin-7 (rAQP7, 269aa) is abundantly expressed in testis. It is involved in water, glycerol and urea transport. Aquaporin-7 is also found in adipose tissue, kidney, and heart. Aquaporin-7 has been localized to in the spermatids and at maturing sperms. Aquaporin families of proteins are predicted to contain six transmembrane domains. The N and C-terminus are predicted to be cytoplasmic.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryAquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function.
      Gene Symbol
      • AQP7
      • Aquaporin-7-like
      • AQP-7
      • AQPap
      • AQP9
      • MGC149555
      • Aquaporin-7
      • MGC149556
      • AQP7L
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O14520 # Forms a channel for water and glycerol.
      SIZE: 342 amino acids; 37232 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      DOMAIN: SwissProt: O14520 Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA).
      SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 12 months.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information



      Reference overviewPub Med ID
      Pressure load: the main factor for altered gene expression in right ventricular hypertrophy in chronic hypoxic rats.
      Baandrup, JD; Markvardsen, LH; Peters, CD; Schou, UK; Jensen, JL; Magnusson, NE; Ørntoft, TF; Kruhøffer, M; Simonsen, U
      PloS one 6 e15859 2011

      Show Abstract Full Text Article
      21246034 21246034

      Data Sheet

      Anti-Aquaporin 7 - Data Sheet

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      Life Science Research > Antibodies and Assays > Primary Antibodies