171610 | Anti-Amyloid Precursor Protein, C-Terminal (751-770) Rabbit pAb

171610
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H Rb Polyclonal Antibody

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      171610-50UL
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      Discontinued
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          Plastic ampoule 50 ul
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          Description
          OverviewRecognizes full-length APP and C-terminal soluble products CTFγ (~6 kDa), CTFα (~9 kDa), and CTFβ (~11 kDa).
        • Antibody Target Gene Symbol: APP
        • Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2
        • Entrez Gene Name: amyloid beta (A4) precursor protein
        • Hu Entrez ID: 351 (Related Antibodies: PC729, PC152,PC151, PC150, PC149, NE1012,171609, 171608, 171607, 171606, 171605, 171604, 171603, 171598, 171537)
        • Mu Entrez ID: 11820
        • Rat Entrez ID: 54226
        • Catalogue Number171610
          Brand Family Calbiochem®
          SynonymsAnti-0443, Anti-APP-CT20
          References
          ReferencesPinnix, I., et al. 2001. J. Biol. Chem. 276, 481.
          Product Information
          DeclarationPurchase of this material is for research use only. Users are invited to request a license from Mayo prior to using the 0433 antibody or any derivatives for clinical diagnostic or therapeutic purposes. For license information, please contact: Mayo Medical Ventures, Office of Technology Commercialization (507) 284-8878, 200 First Street SW, Rochester, MN 55905-001.
          FormLiquid
          Applications
          Key Applications Immunoprecipitation
          Immunoblotting (Western Blotting)
          Immunofluorescence
          Immunohistochemistry
          Application NotesImmunoblotting (1:5000-1:20,000)
          Immunofluorescence (1:1000)
          Immunohistochemistry (1:1000)
          Immunoprecipitation (1:1000)
          Application CommentsVariables associated with assay conditions will dictate the proper working dilution.
          Biological Information
          Immunogena synthetic peptide [(C)KMQQNGYENPTYKFFEQMQN] corresponding to amino acids 751-770 of human precursor protein (APP), conjugated to KLH
          ImmunogenHuman
          HostRabbit
          IsotypeIgG
          Species Reactivity
          • Human
          Antibody TypePolyclonal Antibody
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          171610

          References

          Reference overview
          Pinnix, I., et al. 2001. J. Biol. Chem. 276, 481.

          Brochure

          Title
          Antibody Sourcebook!" Second Edition
          Alzheimer's Disease Brochure & Technical Guide

          Citations

          Title
        • Jonathan D. J. Wrigley, et al. (2005) Functional overexpression of γ-secretase reveals protease independent trafficking functions and a critical role of lipids for protease activity. Journal of Biological Chemistry 280, 12523-12535.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-July-2007 RFH
          SynonymsAnti-0443, Anti-APP-CT20
          ApplicationImmunoblotting (1:5000-1:20,000)
          Immunofluorescence (1:1000)
          Immunohistochemistry (1:1000)
          Immunoprecipitation (1:1000)
          DescriptionRabbit polyclonal antibody supplied as undiluted serum. Recognizes full-length APP and C-terminal soluble products CTFγ (~6 kDa), CTFα (~9 kDa), and CTFβ (~11 kDa).
          BackgroundAmyloid precursor protein (APP) is a type I integral membrane protein with a large N-terminal extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. APP is cleaved by alpha-secretase to generate sAPPα and CTFα, which is the C-terminal membrane, associated product of α-secretase cleavage. α-secretase cleaves in the Aβ domain. β-secretase cleavage of APP at the N-terminal end of the Aβ sequence results in sAPPβ and CTFβ. Both CTFα and CTFβ are cleaved at the C-terminal end of the Aβ transmembrane domain to generate CTFγ. The antibody (171610) detects CTFγ fragment, which migrates at about 6 kDa on SDS-PAGE gels.
          HostRabbit
          Immunogen speciesHuman
          Immunogena synthetic peptide [(C)KMQQNGYENPTYKFFEQMQN] corresponding to amino acids 751-770 of human precursor protein (APP), conjugated to KLH
          IsotypeIgG
          Specieshuman
          FormLiquid
          CommentsVariables associated with assay conditions will dictate the proper working dilution.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesPinnix, I., et al. 2001. J. Biol. Chem. 276, 481.
          Citation
        • Jonathan D. J. Wrigley, et al. (2005) Functional overexpression of γ-secretase reveals protease independent trafficking functions and a critical role of lipids for protease activity. Journal of Biological Chemistry 280, 12523-12535.