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AB5122 | Anti-Adrenergic Receptor Antibody, β 3

50 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA, IHC, WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberAB5122
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Adrenergic Receptor Antibody, β 3
      Product Information
      FormatAffinity Purified
      PresentationAffinity Purified immunoglobulin. Liquid in PBS containing 0.1% BSA
      ApplicationAnti-Adrenergic Receptor Antibody, β 3 detects level of Adrenergic Receptor & has been published & validated for use in ELISA, IH & WB.
      Key Applications
      • ELISA
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL using Chemiluminescence technique

      ELISA: 1:10,000 - 100,000

      Immunohistochemistry: 2-20 μg in formaldehyde fixed tissue.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenA 19 aa sequence at the C-terminus of the human B3AR, splce variant 3 (Emorine et al., 1989; Grannenman et al., 1992; Van Spronsen et al., 1993; Lelias et al., 1993). Control peptide is available under catalog number AG388.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityHuman beta 3 adrenergic receptor (B3AR) is a member of the G-protein coupled receptor superfamily. They typically contain 7 transmembrane domains (Barak et al., 1995) Human B3AR is 408 aa membrane protein (Emorine et al., 1989; Grannenman et al., 1992; Van Spronsen et al., 1993; Lelias et al., 1993).
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe ADRB3 gene product, beta-3-adrenergic receptor, is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Beta adrenergic receptors are involved in the epenephrine and norepinephrine-induced activation of adenylate cyclase through the action of G proteins.
      Gene Symbol
      • ADRB3
      • ADRB3R
      • B3AR
      • BETA3AR
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P13945 # Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
      SIZE: 408 amino acids; 43519 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expressed mainly in adipose tissues.
      SIMILARITY: SwissProt: P13945 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number


      Reference overviewPub Med ID
      Specificity evaluation of antibodies against human β3-adrenoceptors.
      Hana Cernecka,Peter Ochodnicky,Wouter H Lamers,Martin C Michel
      Naunyn-Schmiedeberg's archives of pharmacology 385 2012

      Show Abstract
      22688595 22688595
      {beta}1, {beta}2, {beta}3-Adrenoceptors and NHERF1 Expression in Human Bronchi and Their Modifications in Cystic Fibrosis.
      Bossard F, Silantieff E, Lavazais-Blancou E, Robay A, Sagan C, Rozec B, Gauthier C
      Am J Respir Cell Mol Biol 2010

      Show Abstract
      20203292 20203292
      Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia.
      Rouget, C; Barthez, O; Goirand, F; Leroy, MJ; Breuiller-Fouché, M; Rakotoniaina, Z; Guérard, P; Morcillo, EJ; Advenier, C; Sagot, P; Cabrol, D; Dumas, M; Bardou, M
      Biology of reproduction 74 209-16 2006

      Show Abstract
      16177222 16177222
      The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor.
      Barak, L S, et al.
      Biochemistry, 34: 15407-14 (1995) 1995

      7492540 7492540
      The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes.
      van Spronsen, A, et al.
      Eur. J. Biochem., 213: 1117-24 (1993) 1993

      Show Abstract
      8389293 8389293
      Molecular cloning of a human beta 3-adrenergic receptor cDNA.
      Lelias, J M, et al.
      FEBS Lett., 324: 127-30 (1993) 1993

      Show Abstract
      8389717 8389717
      Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block.
      Granneman, J G, et al.
      Mol. Pharmacol., 42: 964-70 (1992) 1992

      Show Abstract
      1336117 1336117
      Molecular characterization of the human beta 3-adrenergic receptor.
      Emorine, L J, et al.
      Science, 245: 1118-21 (1989) 1989

      Show Abstract
      2570461 2570461

      Data Sheet

      Anti-Adrenergic Receptor, beta 3 - Data Sheet

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