A part of MilliporeSigma

MABE1020 | Anti-Acetyl Lysine, Pan, clone RM101 Antibody

100 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, DB, ICC, IP Rb Affinity Purified Monoclonal Antibody
      Catalogue NumberMABE1020
      DescriptionAnti-Acetyl Lysine, Pan, clone RM101 Antibody
      Background InformationDNA is tightly packed in the nucleus into nucleosomes, generating an environment which is highly repressive towards DNA processes such as transcription. Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression. The acetylation of non-histone proteins such as transcription factors, as well as histones appears to be involved in this process. Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains. The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain. Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit monoclonal IgG in buffer containing PBS with 1% BSA and 0.09% sodium azide.
      ApplicationAnti-Acetyl Lysine, Pan, clone RM101 is an antibody against Acetyl Lysine, Pan for use in WB, Dot Blot, ICC, IP.
      Key Applications
      • Western Blotting
      • Dot Blot
      • Immunocytochemistry
      • Immunoprecipitation
      Application NotesImmunocytochemistry Analysis: A representative lot detected Acetyl Lysine, Pan in A431 cells.
      Dot Blot Analysis: A 1:2,000 dilution from a representative lot detected Acetyl Lysine, Pan in an Absurance™ Histone H3 Antibody Specificity Array (Cat. No. 16-667) and an Absurance™ Histone H2A, H2B, H4 Antibody Specificity Array (Cat. No. 16-665).
      Immunoprecipitation Analysis: A 1:500 dilution from a representative lot immunoprecipitated Acetyl Lysine, Pan in A431 cell lysate.
      Biological Information
      ImmunogenAcetyl lysine-BSA corresponding to all species.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with All based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Purification MethodProtein A Purfied
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Trichostatin A (TSA) treated HeLa cell lysate.

      Western Blotting Analysis: A 1:2,000 of this antibody detected Acetyl Lysine, Pan in Trichostatin A (TSA) treated HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information