A part of MilliporeSigma

AB15467P | Anti-ARG3.1 Antibody

AB15467P
500 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R IHC Rb Purified Polyclonal Antibody
      Description
      Catalogue NumberAB15467P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-ARG3.1 Antibody
      Alternate Names
      • Growth factor ARC
      • Activity regulated cytoskeleton
      Background InformationArc/Arg3.1 is an immediate-early gene whose mRNA is rapidly transcribed and targeted to dendrites of neurons as they engage in information processing and storage. Arc/Arg3.1 is known to be required for durable forms of synaptic plasticity and learning. Arc/Arg3.1 has been shown to be expressed in neuronal cell bodies and dendrites in the brain regions including striatum and cortex hippocampus.
      References
      Product Information
      FormatPurified
      PresentationLyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.
      Applications
      ApplicationAnti-ARG3.1 Antibody detects level of ARG3.1 & has been published & validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:200-1:1,000

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to a region within the C-terminus of human ARG3.1 protein.
      HostRabbit
      SpecificityARG3.1 [Growth factor ARC, Activity regulated cytoskeleton]
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ARC
      • KIAA0278
      • Arg3.1
      • NOP
      • NOL3
      • ARC/ARG3.1
      • MYC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q7LC44 # Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity).
      SIZE: 396 amino acids; 45316 Da
      SUBUNIT: Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 (By similarity).
      SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Endosome (By similarity). Acrosome (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse (By similarity). Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity).
      SIMILARITY: SwissProt: Q7LC44 ## Belongs to the ARC/ARG3.1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.
      Packaging Information
      Material Size500 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-ARG3.1 (IgG FRACTION) POLYCLONAL ANTIBODY -
      RABBIT ANTI-ARG3.1 (IgG FRACTION) POLYCLONAL ANTIBODY - 2208781 2208781
      RABBIT ANTI-ARG3.1 (IgG FRACTION) POLYCLONAL ANTIBODY - 2287764 2287764
      RABBIT ANTI-ARG3.1 (IgG FRACTION) POLYCLONAL ANTIBODY -2504287 2504287
      RABBIT ANTI-ARG3.1 -2798348 2798348

      References

      Reference overviewPub Med ID
      Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
      Shepherd, Jason D, et al
      Neuron, 52:475-84 (2006) 2006

      17088213 17088213

      Data Sheet

      Title
      RABBIT ANTI-ARG3.1 (IgG FRACTION) POLYCLONAL ANTIBODY

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      Alternative Format

      Catalog Number Description  
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      Product Families

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies