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07-181 | Anti-AMPK α-pan Antibody

200 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB Rb Affinity Purified Polyclonal Antibody
      Catalogue Number07-181
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-AMPK α-pan Antibody
      Product Information
      FormatAffinity Purified
      • Rat liver preparation
      PresentationProtein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
      ApplicationAnti-AMPK α-pan Antibody is an antibody against AMPK α-pan for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenhuman AMP-activated protein a1 catalytic subunit (AEKQKHDGRVKIGHYILGD)
      SpecificityRecognizes AMP-activated protein kinase alpha subunits.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
      Gene Symbol
      • PRKAA1
      • MGC57364
      • AMPK
      • AMPK1
      • MGC33776
      • AMPKa1
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13131 # Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
      COFACTOR: Magnesium.
      SIZE: 550 amino acids; 62808 Da
      SUBUNIT: Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic subunits. Interacts with FNIP1.
      SIMILARITY: SwissProt: Q13131 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. & Contains 1 protein kinase domain.
      Molecular Weight63 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on a rat liver protein preparation
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-AMP-Activated Protein Kinase (AMPK) a-pan (rabbit polyclonal IgG) - 2201574 2201574
      Anti-AMP-Activated Protein Kinase (AMPK) a-pan (rabbit polyclonal IgG) - 2361820 2361820
      Anti-AMP-Activated Protein Kinase (AMPK) α-pan 2480587
      Anti-AMP-Activated Protein Kinase (AMPK) α-pan (rabbit polyclonal IgG) - 2392277 2392277
      Anti-AMPK alpha;-pan - 20346 20346
      Anti-AMPK alpha;-pan - 22456 22456
      Anti-AMPK alpha;-pan - 30183 30183


      Reference overviewApplicationPub Med ID
      Xanthene derivatives increase glucose utilization through activation of LKB1-dependent AMP-activated protein kinase.
      Kwon, Y; Song, P; Yoon, JH; Ghim, J; Kim, D; Kang, B; Lee, TG; Kim, JA; Choi, JK; Youn, IK; Lee, HK; Ryu, SH
      PloS one 9 e108771 2014

      Show Abstract
      25250787 25250787
      Neuroprotective Effects of AMP-Activated Protein Kinase on Scopolamine Induced Memory Impairment.
      Kim, SJ; Lee, JH; Chung, HS; Song, JH; Ha, J; Bae, H
      The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 17 331-8 2013

      Show Abstract
      23946693 23946693
      Erythropoietin administration acutely stimulates resting energy expenditure in healthy young men.
      Christensen, B; Vendelbo, MH; Krusenstjerna-Hafstrøm, T; Madsen, M; Pedersen, SB; Jessen, N; Møller, N; Jørgensen, JO
      Journal of applied physiology (Bethesda, Md. : 1985) 112 1114-21 2012

      Show Abstract
      22241056 22241056
      Cold tolerance, cold-induced hyperphagia, and nonshivering thermogenesis are normal in α₁-AMPK-/- mice.
      Bauwens, JD; Schmuck, EG; Lindholm, CR; Ertel, RL; Mulligan, JD; Hovis, I; Viollet, B; Saupe, KW
      American journal of physiology. Regulatory, integrative and comparative physiology 301 R473-83 2011

      Show Abstract
      Western Blotting21593427 21593427
      Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53.
      Kim, HS; Hwang, JT; Yun, H; Chi, SG; Lee, SJ; Kang, I; Yoon, KS; Choe, WJ; Kim, SS; Ha, J
      The Journal of biological chemistry 283 3731-42 2008

      Show Abstract
      18079115 18079115
      Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
      Lin, J; Wu, PH; Tarr, PT; Lindenberg, KS; St-Pierre, J; Zhang, CY; Mootha, VK; Jäger, S; Vianna, CR; Reznick, RM; Cui, L; Manieri, M; Donovan, MX; Wu, Z; Cooper, MP; Fan, MC; Rohas, LM; Zavacki, AM; Cinti, S; Shulman, GI; Lowell, BB; Krainc, D; Spiegelman, BM
      Cell 119 121-35 2004

      Show Abstract
      15454086 15454086