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ABC40 | Anti-AIP1/Alix Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, M, H WB, ICC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABC40
      DescriptionAnti-AIP1/Alix Antibody
      Alternate Names
      • Programmed cell death 6-interacting protein
      • ALG-2-interacting protein 1
      • ALG-2-interacting protein X
      • E2F1-inducible protein
      • Eig2
      Background InformationProgrammed cell death 6-interacting protein (UniProt: Q9WU78; also known as ALG-2-interacting protein 1, ALG-2-interacting protein X, E2F1-inducible protein, Eig2) is encoded by the Pdcd6ip (also known as Aip1, Alix) gene (Gene ID: 18571) in murine species. AIP1 is a class E VPS cytoplasmic, ubiquitously expressed protein that is involved in concentration and sorting of cargo proteins of the multi-vesicular body (MVB) for incorporation into intra-lumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. AIP1 interacts with ALG-2 (apoptosis-linked gene-2) to regulate cell death. This interaction is strictly dependent on calcium. AIP1 is considered to be essential for the maintenance of fibroblast morphology and has been shown to play a role in the regulation of both apoptosis and cell proliferation. AIP1 is also known to regulate exosome biogenesis in concert with SDC1/4 and SDCBP. AIP1 can undergo phosphorylated on tyrosine residues by activated platelet-derived growth factor receptor-beta (PDGFRB).
      Product Information
      FormatAffinity Purified
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal antibody in buffer containing 20 mM Tris-HCl, pH 7.2, 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect Programmed cell death 6-interacting protein using this rabbit polyclonal Anti-AIP1/Alix, Cat. No. ABC40 that has been tested in Immunocytochemistry and Western blotting.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 2.5 µg/mL from a representative lot detected AIP1/Alix in HeLa and NIH3T3 cells.
      Biological Information
      ImmunogenGST-tagged recombinant fragment corresponding to 479 amino acids from the C-terminal half of mouse AIP1/Alix.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis polyclonal antibody specifically detects AIP1 in Jurkat cells. It is likely to react with isoforms 1, 2, and 3.
      Species Reactivity
      • Rat
      • Mouse
      • Human
      Species Reactivity NoteHuman, Mouse, Rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Pdcd6ip
      • Aip1
      • Alix
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~95 kDa observed; 96.02 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

      Western Blotting Analysis: 0.1 µg/mL of this antibody detected AIP1/Alix in 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-AIP1/Alix - 2388320 2388320
      Anti-AIP1/Alix - 2461579 2461579
      Anti-AIP1/Alix - 1984695 1984695
      Anti-AIP1/Alix - 2080289 2080289
      Anti-AIP1/Alix - 2109560 2109560
      Anti-AIP1/Alix - 2151865 2151865
      Anti-AIP1/Alix - 2179360 2179360
      Anti-AIP1/Alix - 2210376 2210376
      Anti-AIP1/Alix - 2280480 2280480
      Anti-AIP1/Alix - 2302250 2302250
      Anti-AIP1/Alix - 2343900 2343900
      Anti-AIP1/Alix - NRG1832113 NRG1832113
      Anti-AIP1/Alix -2495495 2495495
      Anti-AIP1/Alix -2520506 2520506
      Anti-AIP1/Alix -2601730 2601730
      Anti-AIP1/Alix -2649267 2649267
      Anti-AIP1/Alix -2707787 2707787
      Anti-AIP1/Alix -2734444 2734444
      Anti-AIP1/Alix -2793603 2793603


      Reference overviewPub Med ID
      Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers.
      Lugli, G; Cohen, AM; Bennett, DA; Shah, RC; Fields, CJ; Hernandez, AG; Smalheiser, NR
      PloS one 10 e0139233 2015

      Show Abstract
      26426747 26426747