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ABT348 | Anti-AGBL2 Antibody

ABT348
150 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB, IF Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABT348
      DescriptionAnti-AGBL2 Antibody
      Alternate Names
      • Cytosolic carboxypeptidase 2
      • ATP/GTP-binding protein-like 2
      • AGBL2
      Background InformationThe protein named Cytosolic carboxypeptidase 2, or alternatively ATP/GTP binding protein-like 2, and encoded by the human gene named AGBL2 or CCP2, is cytoplasmic metallocarboxypeptidase involved in tubulin processing. AGBL2 detyrosinates the C-terminal EEY region of alpha tubulin and thus is important in the regulation of microtubule dynamics, which is important for cell motility and division, particularly in cancer cells. Thus because AGBL2 is the enzyme that initiates the activity it is being examined as a possible target for anti-cancer therapy. AGBL2 also interacts with other cancer related proteins such as RARRES1. EMD-Millipore’s Anti-AGBL2 rabbit polyclonal antibody has been tested in western blotting on mouse lung tissue extracts and in fluorescent immunocytochemistry on MCF-7 cells in culture.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol.
      Applications
      ApplicationDetect Carboxypeptidase using this rabbit polyclonal antibody, Anti-AGBL2 Antibody validated for use in western blotting & Immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunofluorescence
      Application NotesImmunofluorescence Analysis: A 1:50 dilution from a representative lot detected AGBL2 in MCF-7 cells.
      Biological Information
      ImmunogenGST-tagged fusion protein corresponding to human AGBL2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • AGBL2
      • CCP2
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~104 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse lung tissue lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected AGBL2 in mouse lung tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size150 µL
      Transport Information
      Supplemental Information
      Specifications