A part of MilliporeSigma

MABT175 | Anti-ADAMTS5 Antibody, clone 3A2.1

100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
Limited Quantities Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers


      Contact Customer Service

      Click To Print This Page


      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IH(P) M Purified Monoclonal Antibody
      Catalogue NumberMABT175
      DescriptionAnti-ADAMTS5 Antibody, clone 3A2.1
      Alternate Names
      • A disintegrin and metalloproteinase with thrombospondin motifs 5
      • ADAM-TS 5
      • ADAM-TS5
      • ADAMTS-5
      • EC 3.4.24.-
      • A disintegrin and metalloproteinase with thrombospondin motifs 11
      • ADAM-TS 11
      • ADAMTS-11
      • ADMP-2
      • Aggrecanase-2
      Background InformationThe ADAMTS (A Disintegrin and Metalloprotease with Thrombospondin motifs) family of secreted proteases comprises at least 20 members in mammals, and several members in invertebrates. ADAMTS members resemble the membrane-bound ADAM family of proteases in the presence of a prodomain, a catalytic domain and a disintegrin-like domain. However, ADAMTS members lack a transmembrane domain, and instead contain varying numbers of thrombospondin type I modules. ADAMTS-5, along with ADAMTS-4, cleaves aggrecan between Glu373 and Ala374, a physiological cleavage site in arthritic cartilage. In addition, expression of ADAMTS-5 is elevated in human chondrocytes treated with inflammatory cytokine interleukin-1, but is constitutively expressed in bovine cartilage explants. 70 and 53 kD forms of ADAMTS-5 have been shown to be present at varying ratios in fibroblast-like synoviocytes and extracts of rheumatoid arthritis, osteoarthritis and normal synovial tissue.
      Product Information
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect ADAMTS5 using this Anti-ADAMTS5 Antibody, clone 3A2.1 validated for use in IHC (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of human ADAMTS5.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ADAMTS5
      • ADAMTS11
      • ADMP2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight101.7 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human thalamus tissue.

      Imunnohistochemistry Analysis: A 1:50 dilution of this antibody detected ADAMTS5 in human thalamus tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information