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MABE903 | Anti-ACD Antibody, clone 1G10.3

MABE903
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ICC M Affinity Purified Monoclonal Antibody
      Description
      Catalogue NumberMABE903
      DescriptionAnti-ACD Antibody, clone 1G10.3
      Alternate Names
      • ACD
      • Adrenocortical dysplasia protein homolog
      • POT1 and TIN2-interacting protein
      Background InformationAdrenocortical dysplasia protein homolog (also known as POT1 and TIN2 organizing protein or TIN2-interacting protein) is a nuclear protein encoded by the ACD gene in human (also known as PIP1, PTOP, TINT1, TPP1). It a component of the shelterin complex (telosome) and is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance, and chromosome ends are inappropriately processed by DNA repair pathways. The ACD-POT1 heterodimer is reported to enhance telomere elongation by increasing telomerase processivity (PMID 17237768).
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-ACD Antibody, clone 1G10.3 is an antibody against ACD for use in Western Blotting and Immunocytochemistry.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 4.0 µg/mL from a representative lot detected ACD in HeLa, A431, and NIH/3T3 cells.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human ACD.
      Clone1G10.3
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ACD
      • PIP1
      • PTOP
      • TINT1
      • TPP1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~60 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa nuclear extract.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected ACD in 10 µg of HeLa nuclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications