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36-009 | Anti-β-Synuclein Antibody, clone Syn207

36-009
200 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, IHC M Ascites Monoclonal Antibody
      Description
      Catalogue Number36-009
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-β-Synuclein Antibody, clone Syn207
      References
      Product Information
      FormatAscites
      Presentationascites with 0.05% sodium azide
      Applications
      ApplicationAnti-β-Synuclein Antibody, clone Syn207 is an antibody against β-Synuclein for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      Immunogenfull length recombinant human β-Synuclein
      Cloneclone Syn207
      HostMouse
      Specificityrecombinant β-Synuclein
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
      Gene Symbol
      • SNCB
      • beta-synuclein
      • Beta-synuclein.
      Purification MethodAscites
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q16143 # Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
      SIZE: 134 amino acids; 14288 Da
      SUBCELLULAR LOCATION: Cytoplasm.
      TISSUE SPECIFICITY: Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
      PTM: Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
      DISEASE: SwissProt: Q16143 # Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.
      SIMILARITY: SwissProt: Q16143 ## Belongs to the synuclein family.
      Molecular Weight~17kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot lot detected β-Synuclein recombinant protein
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-#946;-Synuclein, clone Syn207 (mouse ascites) - 2141824 2141824
      Anti-b-Synuclein, clone Syn207 (mouse ascites) - 1999454 1999454
      Anti-b-Synuclein, clone Syn207 (mouse ascites) - 2011458 2011458
      Anti-b-Synuclein, clone Syn207 (mouse ascites) - 2110003 2110003
      Anti-b-Synuclein, clone Syn207 - DAM18177125 DAM18177125
      Anti-b-Synuclein, clone Syn207 - NG1896098 NG1896098
      Anti-beta;-Synuclein, clone Syn207 - 26829 26829
      Anti-β-Synuclein, clone Syn207 (mouse ascites) - 2391417 2391417
      Anti-β-Synuclein, clone Syn207 (mouse ascites) - 2446752 2446752

      References

      Reference overviewApplicationPub Med ID
      Localization of synucleins in the mammalian cochlea.
      Akil, O; Weber, CM; Park, SN; Ninkina, N; Buchman, V; Lustig, LR
      Journal of the Association for Research in Otolaryngology : JARO 9 452-63 2008

      Show Abstract Full Text Article
      18665422 18665422
      Oxidative modifications of alpha-synuclein.
      Ischiropoulos, Harry
      Ann. N. Y. Acad. Sci., 991: 93-100 (2003) 2003

      Show Abstract
      12846977 12846977
      Oxidative stress and nitration in neurodegeneration: cause, effect, or association?
      Ischiropoulos, Harry and Beckman, Joseph S
      J. Clin. Invest., 111: 163-9 (2003) 2003

      12531868 12531868
      Alpha-synuclein: its biological function and role in neurodegenerative diseases.
      Kaplan, Batia, et al.
      J. Mol. Neurosci., 20: 83-92 (2003) 2003

      Show Abstract
      12794302 12794302
      Development of new treatments for Parkinson's disease in transgenic animal models: a role for beta-synuclein.
      Masliah, Eliezer and Hashimoto, Makoto
      Neurotoxicology, 23: 461-8 (2002) 2002

      Show Abstract
      12428718 12428718
      A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease
      Giasson, B. I., et al
      J Neurosci Res, 59:528-33 (2000) 2000

      Immunoblotting (Western), Immunohistochemistry (Tissue)10679792 10679792
      Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.
      Tu, P H, et al.
      Ann. Neurol., 44: 415-22 (1998) 1998

      Show Abstract
      Immunoblotting (Western)9749615 9749615

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies