176708 Angiostatin K1-3, Human, Recombinant, E. coli

176708
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      176708-250UG
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      Limited AvailabilityLimited Availability
      Stocked 
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          Glass bottle 250 μg
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          Description
          OverviewRecombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED50=70 nM) relative to kringles 1-4 (ED50=135 nm).
          Catalogue Number176708
          Brand Family Calbiochem®
          SynonymsAng K1-3, K1-3, rHuAng K1-3
          References
          ReferencesCao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728.
          Cao, E., et al. 1997. J. Biol. Chem. 272, 22924.
          Sim, B.K., et al. 1997. Cancer Res. 57, 1329.
          Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651.
          O'Rieilly, M.S., et al. 1994. Cell 79, 315.
          Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104.
          Forsgren, M., et al. 1987. FEBS Lett. 213, 254.
          Malinowski, D.P., et al. 1984. Biochemistry 23, 4243.
          Product Information
          FormLyophilized powder
          FormulationLyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.
          Applications
          Biological Information
          Purity≥95% by HPLC and SDS-PAGE
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          176708

          References

          Reference overview
          Cao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728.
          Cao, E., et al. 1997. J. Biol. Chem. 272, 22924.
          Sim, B.K., et al. 1997. Cancer Res. 57, 1329.
          Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651.
          O'Rieilly, M.S., et al. 1994. Cell 79, 315.
          Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104.
          Forsgren, M., et al. 1987. FEBS Lett. 213, 254.
          Malinowski, D.P., et al. 1984. Biochemistry 23, 4243.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-July-2010 RFH
          SynonymsAng K1-3, K1-3, rHuAng K1-3
          DescriptionRecombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED50=70 nM) relative to kringles 1-4 (ED50=135 nm).
          FormLyophilized powder
          FormulationLyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.
          Purity≥95% by HPLC and SDS-PAGE
          SolubilityH2O or Aqueous Buffer Containing 0.1% BSA
          Storage -20°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesCao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728.
          Cao, E., et al. 1997. J. Biol. Chem. 272, 22924.
          Sim, B.K., et al. 1997. Cancer Res. 57, 1329.
          Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651.
          O'Rieilly, M.S., et al. 1994. Cell 79, 315.
          Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104.
          Forsgren, M., et al. 1987. FEBS Lett. 213, 254.
          Malinowski, D.P., et al. 1984. Biochemistry 23, 4243.