175600 Angiogenin, Human, Recombinant, E. coli

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
175600
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      Overview

      Replacement Information

      Key Specifications Table

      Purity
      ≥95% by SDS-PAGE

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      175600-50UG
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      Stocked 
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          		 Plastic ampoule 50 μg
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          Description
          OverviewRecombinant, human angiogenin expressed in E. coli. Exhibits angiogenic and ribonucleolytic activities. Enhances the ability of endothelial cells to digest extracellular matrix components and degrade basement membrane. Has been shown to stimulate capillary and umbilical vein endothelial cells to produce DAG and secrete prostacyclin by phospholipase activation. Biological activity: 1.0 µg protein produces an absorbance change at 260 nm of approximately 2.0 - 3.0 as measured by yeast tRNA ribonucleolytic activity.
          Catalogue Number175600
          Brand Family Calbiochem®
          References
          ReferencesLeland, P.A., et al. 2002. Biochemistry 41, 1343.
          Hatzi, E., et al. 2000. Biochem. Biophys. Res. Commun. 267, 719.
          Hu, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 12096.
          Lee, F.S., and Vallee, B.L. 1989. Biochem. Biophys. Res. Commun. 161, 121.
          Kurachi, R., et al. 1985. Biochemistry 24, 5494.
          Product Information
          FormSolid
          FormulationLyophilized from sterile-filtered PBS containing 50 µg BSA/µg Angiogenin.
          Applications
          Biological Information
          Biological activity≥1.0 µg protein produces an absorbance change at 260 nm of ~2.0-3.0 as measured based upon its ribonucleolytic activity toward Yeast tRNA.
          Purity≥95% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxins: ≤100 pg/µg Angiogenin
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to months at -70°C. Avoid freeze/thaw cycles of solutions.
          Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          175600

          References

          Reference overview
          Leland, P.A., et al. 2002. Biochemistry 41, 1343.
          Hatzi, E., et al. 2000. Biochem. Biophys. Res. Commun. 267, 719.
          Hu, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 12096.
          Lee, F.S., and Vallee, B.L. 1989. Biochem. Biophys. Res. Commun. 161, 121.
          Kurachi, R., et al. 1985. Biochemistry 24, 5494.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-November-2009 JSW
          DescriptionRecombinant, human angiogenin expressed in E. coli. A 14 kDa protein with angeogenic and ribonucleolytic activities. Enhances the proteolytic and fibrinolytic activities of endothelial cells. Also, stimulates the endothelial cell invasion of Matrigel basement membrane. Has been shown to stimulate capillary and umbilical vein endothelial cells to produce DAG and secrete prostacyclin by phospholipase activation.
          FormSolid
          FormulationLyophilized from sterile-filtered PBS containing 50 µg BSA/µg Angiogenin.
          Purity≥95% by SDS-PAGE
          ContaminantsEndotoxins: ≤100 pg/µg Angiogenin
          Biological activity≥1.0 µg protein produces an absorbance change at 260 nm of ~2.0-3.0 as measured based upon its ribonucleolytic activity toward Yeast tRNA.
          SolubilityReconstitute to a concentration ≥1 µg/ml with sterile PBS containing ≥0.1% HSA or BSA.
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to months at -70°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesLeland, P.A., et al. 2002. Biochemistry 41, 1343.
          Hatzi, E., et al. 2000. Biochem. Biophys. Res. Commun. 267, 719.
          Hu, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 12096.
          Lee, F.S., and Vallee, B.L. 1989. Biochem. Biophys. Res. Commun. 161, 121.
          Kurachi, R., et al. 1985. Biochemistry 24, 5494.