176695 Angeli’s Salt - CAS 13826-64-7 - Calbiochem

176695
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      N₂O₃ · 2Na 13826-64-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      176695-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA nitroxyl anion (NO) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) in 100 mM phosphate buffer, pH 7.4 is 2.3 minutes at 37°C. Decomposition is nearly instantaneous at pH 5.0.
          Catalogue Number176695
          Brand Family Calbiochem®
          SynonymsAS, Sodium Trioxodinitrate, Sodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate
          References
          ReferencesMiranda, K.M., et al. 2001. J. Biol. Chem. 276, 1720.
          Hrinczenko, B.W., et al. 2000. Br. J. Haematol. 110, 412.
          Nelli, S., et al. 2000. Br. J. Pharmacol. 131, 356.
          Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 14617.
          Keefer, L.K., et al. 1996. Methods Enzymol. 268, 281.
          Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 707.
          Maragos, C.M., et al. 1991. J. Med. Chem. 34, 3242.
          Product Information
          CAS number13826-64-7
          ATP CompetitiveN
          FormCrystalline solid
          Hill FormulaN₂O₃ · 2Na
          Chemical formulaN₂O₃ · 2Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNitroxyl anion (NO-) donor
          Purity≥99%
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in alkaline solution, store at -20°C. This product is stable for 6 months as supplied. Alkaline stock solutions are stable for up to 24 h at -20°C. Unstable in acidic or neutral pH buffers.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          176695

          References

          Reference overview
          Miranda, K.M., et al. 2001. J. Biol. Chem. 276, 1720.
          Hrinczenko, B.W., et al. 2000. Br. J. Haematol. 110, 412.
          Nelli, S., et al. 2000. Br. J. Pharmacol. 131, 356.
          Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 14617.
          Keefer, L.K., et al. 1996. Methods Enzymol. 268, 281.
          Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 707.
          Maragos, C.M., et al. 1991. J. Med. Chem. 34, 3242.

          Brochure

          Title
          Nitric Oxide Donors and Scavengers Technical Bulletin
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2018 JSW
          SynonymsAS, Sodium Trioxodinitrate, Sodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate
          DescriptionA nitroxyl anion (NO-) donor that spontaneously, in the presence of oxygen and Cu2+ and Fe3+, dissociates in a pH-dependent, first-order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) of NO release = 2.3 min. (in 100 mM phosphate buffer, pH 7.4 at 37°C). Induces relaxation of norepinephrine-constricted rabbit aorta (EC50 = 590 nM). Angeli's Salt produces nitroxyl anion (NO-) that can be converted to NO in the presence of heme.
          FormCrystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number13826-64-7
          Chemical formulaN₂O₃ · 2Na
          Structure formulaStructure formula
          Purity≥99%
          SolubilityAlkaline solutions (0.01 M NaOH)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in alkaline solution, store at -20°C. This product is stable for 6 months as supplied. Alkaline stock solutions are stable for up to 24 h at -20°C. Unstable in acidic or neutral pH buffers.
          Toxicity Standard Handling
          ReferencesMiranda, K.M., et al. 2001. J. Biol. Chem. 276, 1720.
          Hrinczenko, B.W., et al. 2000. Br. J. Haematol. 110, 412.
          Nelli, S., et al. 2000. Br. J. Pharmacol. 131, 356.
          Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 14617.
          Keefer, L.K., et al. 1996. Methods Enzymol. 268, 281.
          Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 707.
          Maragos, C.M., et al. 1991. J. Med. Chem. 34, 3242.