172104 Anaphase-Promoting Complex Inhibitor, TAME - CAS 1784-03-8 - Calbiochem

172104
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      172104-50MG
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          Glass bottle 50 mg
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          Description
          OverviewTAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50 = 12 µM.
          Catalogue Number172104
          Brand Family Calbiochem®
          SynonymsTAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I
          References
          ReferencesSackton, K.L., et al. 2014. Nature. In press.
          Zeng, X., et al. 2010. Cancer Cell 18, 382.
          Product Information
          CAS number1784-03-8
          FormWhite solid
          Hill FormulaC₁₄H₂₂N₄O₄S · HCl
          Chemical formulaC₁₄H₂₂N₄O₄S · HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          172104

          References

          Reference overview
          Sackton, K.L., et al. 2014. Nature. In press.
          Zeng, X., et al. 2010. Cancer Cell 18, 382.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-April-2012 JSW
          SynonymsTAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I
          DescriptionTAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50 = 12 µM.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1784-03-8
          Chemical formulaC₁₄H₂₂N₄O₄S · HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSackton, K.L., et al. 2014. Nature. In press.
          Zeng, X., et al. 2010. Cancer Cell 18, 382.