164640 Aminopurvalanol A - CAS 220792-57-4 - Calbiochem

164640
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₆ClN₇O 220792-57-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      164640-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 = ~ 1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~ 100-fold greater selectivity over a panel of kinases tested (IC50 ≥ 2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
          Catalogue Number164640
          Brand Family Calbiochem®
          Synonyms(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
          References
          ReferencesBreton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
          Knockaert, M., et al. 2002.Oncogene 21, 6413.
          Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
          Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
          Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
          Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.
          Product Information
          CAS number220792-57-4
          ATP CompetitiveY
          DeclarationSold under license of U.S. Patent 6,255,485 and 6,617,331.
          FormPale yellow solid
          Hill FormulaC₁₉H₂₆ClN₇O
          Chemical formulaC₁₉H₂₆ClN₇O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35
          Primary Target IC<sub>50</sub>33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          164640

          References

          Reference overview
          Breton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
          Knockaert, M., et al. 2002.Oncogene 21, 6413.
          Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
          Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
          Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
          Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.

          Brochure

          Title
          DNA Repair Pathway Poster
          MAPK Pathway Poster ( 750 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-April-2008 RFH
          Synonyms(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
          DescriptionA cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 ~1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~100-fold greater selectivity over a panel of kinases tested (IC50 ≥2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number220792-57-4
          Chemical formulaC₁₉H₂₆ClN₇O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (40 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesBreton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
          Knockaert, M., et al. 2002.Oncogene 21, 6413.
          Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
          Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
          Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
          Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.