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129874 | Amifostine - CAS 20537-88-6 - Calbiochem

129874
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₅H₁₅N₂O₃PS •3H₂O 20537-88-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      129874-50MG
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      Stocked 
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      Available
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          Glass bottle 50 mg
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          Description
          OverviewA cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs. Its cytoprotective activities have been attributed to its free radical scavenging properties of its active thiol metabolite, WR-1065. The critical step in its activation is its interaction with alkaline phosphatase that is differentially distributed in normal and neoplastic cells. A strong inducer of hypoxia-inducible factor-α1 (HIF-α1) and p53. Shown to reduce PARP proteolysis and levels of active caspase-3 in irradiated mouse ovaries.
          Catalogue Number129874
          Brand Family Calbiochem®
          Synonyms2-(3-Aminopropyl)aminoethyl phosphorothioate, trihydrate, S-2-(3-Aminopropylamino)ethyl-O,O-dihydrogen phosphorothioate, trihydrate
          References
          ReferencesDedieu, S., et al. 2010. BMC Medicine 8, 19.
          Yoon, Y.D., et al. 2005. In Vivo 19, 509.
          Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
          Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.
          Product Information
          CAS number20537-88-6
          FormOff-white solid
          Hill FormulaC₅H₁₅N₂O₃PS •3H₂O
          Chemical formulaC₅H₁₅N₂O₃PS •3H₂O
          Structure formula Image
          Applications
          Biological Information
          Purity≥99% by NMR
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          129874

          References

          Reference overview
          Dedieu, S., et al. 2010. BMC Medicine 8, 19.
          Yoon, Y.D., et al. 2005. In Vivo 19, 509.
          Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
          Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-May-2012 JSW
          Synonyms2-(3-Aminopropyl)aminoethyl phosphorothioate, trihydrate, S-2-(3-Aminopropylamino)ethyl-O,O-dihydrogen phosphorothioate, trihydrate
          DescriptionA cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs. Its cytoprotective activities have been attributed to its free radical scavenging properties of its active thiol metabolite, WR-1065. The critical step in its activation is its interaction with alkaline phosphatase that is differentially distributed in normal and neoplastic cells. A strong inducer of hypoxia-inducible factor-α1 (HIF-α1) and p53. Shown to reduce PARP proteolysis and levels of active caspase-3 in irradiated mouse ovaries.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number20537-88-6
          Chemical formulaC₅H₁₅N₂O₃PS •3H₂O
          Structure formula
          Purity≥99% by NMR
          SolubilityH₂O
          Storage +2°C to +8°C
          Protect from light
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesDedieu, S., et al. 2010. BMC Medicine 8, 19.
          Yoon, Y.D., et al. 2005. In Vivo 19, 509.
          Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
          Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.