124011 | Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem

124011
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₁H₂₇IN₄S 681281-88-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      124011-1MG
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          Glass bottle 1 mg
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          124011-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K. A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124015) in DMSO is also available.
              Catalogue Number124011
              Brand Family Calbiochem®
              References
              ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



              Selected Citations
              Lee, J., et al. 2009. Cell Stem Cell 5, 76.


              Product Information
              CAS number681281-88-9
              ATP CompetitiveN
              FormYellow solid
              Hill FormulaC₃₁H₂₇IN₄S
              Chemical formulaC₃₁H₂₇IN₄S
              Hygroscopic Hygroscopic
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              ApplicationAkt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K.
              Biological Information
              Primary TargetAkt
              Primary Target IC<sub>50</sub>625 nM in blocking Akt-mediated FOXO1a nuclear export; < 1.25 µM in blocking Akt-mediated cell proliferation in 786-O cells
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              124011

              References

              Reference overview
              Kau, T.R., et al. 2003. Cancer Cell 4, 463.



              Selected Citations
              Lee, J., et al. 2009. Cell Stem Cell 5, 76.


              Brochure

              Title
              Akt Brochure
              Akt Pathway Poster

              Citations

              Title
            • Chengyu Wu and Jiaoti Huang. (2007) Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer. Journal of Biological Chemistry 282, 3571-3583.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision23-November-2009 RFH
              DescriptionA cell-permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3-K.
              FormYellow solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number681281-88-9
              Chemical formulaC₃₁H₂₇IN₄S
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMSO (5 mg/ml)
              Storage +2°C to +8°C
              Hygroscopic
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



              Selected Citations
              Lee, J., et al. 2009. Cell Stem Cell 5, 76.


              Citation
            • Chengyu Wu and Jiaoti Huang. (2007) Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer. Journal of Biological Chemistry 282, 3571-3583.