124008 Akt Inhibitor II - Calbiochem

124008
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₉H₅₉O₁₀P

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      124008-1MG
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      Stocked 
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit ~50% of PKA activity.
          Catalogue Number124008
          Brand Family Calbiochem®
          SynonymsSH-5
          References
          ReferencesGills, J.J., et al. 2007. J. Biol. Chem. in press.
          Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₉H₅₉O₁₀P
          Chemical formulaC₂₉H₅₉O₁₀P
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationAkt Inhibitor II, CAS 701976-54-7, is a cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt & downstream substrates.
          Biological Information
          Primary TargetAkt
          Purity≥98% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          124008

          References

          Reference overview
          Gills, J.J., et al. 2007. J. Biol. Chem. in press.
          Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.

          Brochure

          Title
          Akt Brochure
          Akt Pathway Poster
          Protein Kinase Assay and Detection Kits Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-November-2009 RFH
          SynonymsSH-5
          DescriptionA cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and selected downstream substrates without affecting the phosphorylation of PDK-1 and other downstream kinases. Decreases phosphorylation of Akt without affecting the total Akt level. Reported to be a potent inducer of apoptosis and to selectively kill a variety of cancer cell lines expressing high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit ~50% of PKA activity.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₉H₅₉O₁₀P
          Structure formulaStructure formula
          Purity≥98% by NMR
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesGills, J.J., et al. 2007. J. Biol. Chem. in press.
          Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.