124005 Akt Inhibitor - Calbiochem

124005
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₀H₅₈O₁₀

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      124005-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1 - 10 µM range.
          Catalogue Number124005
          Brand Family Calbiochem®
          Synonyms1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
          References
          ReferencesHu, Y., et al. 2000 J. Med. Chem. 43, 3045.
          Product Information
          ATP CompetitiveY
          FormWhite to off-white solid
          Hill FormulaC₃₀H₅₈O₁₀
          Chemical formulaC₃₀H₅₈O₁₀
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationThis Akt inhibitor is a cell-permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (IC50 of 5.0 µM).
          Biological Information
          Primary TargetAkt
          Primary Target IC<sub>50</sub>5.0 µM for Akt (PKB)
          Purity≥98% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          124005

          References

          Reference overview
          Hu, Y., et al. 2000 J. Med. Chem. 43, 3045.

          Brochure

          Title
          Akt Brochure
          Akt Pathway Poster
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-June-2011 JSW
          Synonyms1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
          DescriptionA cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1-10 µM range.
          FormWhite to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₀H₅₈O₁₀
          Structure formulaStructure formula
          Purity≥98% by NMR
          SolubilityDMSO (200 mg/ml). Use anhydrous DMSO for reconstitution.
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
          Toxicity Standard Handling
          ReferencesHu, Y., et al. 2000 J. Med. Chem. 43, 3045.