119151 | Adenosine A2B Receptor Antagonist I, MRS 1754 - CAS 264622-58-4 - Calbiochem

119151
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      119151-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA p-cyanoanilide xanthine derivative that acts as a highly selective, high affinity antagonist of adenosine A2B receptor (A2BR; Ki = 1.97 nM for human A2BR). Does not significantly affect other adenosine receptors (Ki = 403 nM, 503 nM, and 570 nM for human A1R, A2AR, and A3R, respectively). Exhibits some antagonist action on rat A1R (Ki = 16.8 nM). Shown to abolish the cardioprotective effects of NECA (Cat. No. 119140).
          Catalogue Number119151
          Brand Family Calbiochem®
          Synonyms8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine, MRS-1754, MRS1754
          References
          ReferencesJi, X., et al. 2001. Biochem Pharmacol. 61, 657.
          Philipp, S., et al. 2006. Cardiovasc Res. 70, 308.
          Kim, Y. C., et al. 2000. J Med Chem. 43, 1165.
          Kreckler, L. M., et al. 2006. J Pharmacol Exp Ther. 331.
          Ma, D.F., et al. 2010. Hum Pathol. 41, 1550.
          Product Information
          CAS number264622-58-4
          FormWhite solid
          Hill FormulaC₂₆H₂₆N₆O₄
          Chemical formulaC₂₆H₂₆N₆O₄
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAdenosine A2B Receptor
          Primary Target K<sub>i</sub>1.97 nM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          119151

          References

          Reference overview
          Ji, X., et al. 2001. Biochem Pharmacol. 61, 657.
          Philipp, S., et al. 2006. Cardiovasc Res. 70, 308.
          Kim, Y. C., et al. 2000. J Med Chem. 43, 1165.
          Kreckler, L. M., et al. 2006. J Pharmacol Exp Ther. 331.
          Ma, D.F., et al. 2010. Hum Pathol. 41, 1550.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-March-2013 JSW
          Synonyms8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine, MRS-1754, MRS1754
          DescriptionA p-cyanoanilide xanthine derivative that acts as a highly selective, high affinity antagonist of adenosine A2B receptor (A2BR; Ki = 1.97 nM for human A2BR). Does not significantly affect other adenosine receptors (Ki = 403 nM, 503 nM, and 570 nM for human A1R, A2AR, and A3R, respectively). Exhibits some antagonist action on rat A1R (Ki = 16.8 nM). Shown to abolish the cardioprotective effects of NECA (Cat. No. 119140).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number264622-58-4
          Chemical formulaC₂₆H₂₆N₆O₄
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (50 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesJi, X., et al. 2001. Biochem Pharmacol. 61, 657.
          Philipp, S., et al. 2006. Cardiovasc Res. 70, 308.
          Kim, Y. C., et al. 2000. J Med Chem. 43, 1165.
          Kreckler, L. M., et al. 2006. J Pharmacol Exp Ther. 331.
          Ma, D.F., et al. 2010. Hum Pathol. 41, 1550.