119137 | Adenosine A2A Receptor Agonist I, CGS 21680, Hydrochloride - CAS 124182-57-6 - Calbiochem

119137
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      119137-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA xanthin derivative that acts as a potent agonist of adenosine A2A receptors (Ki = 27 nM). Exhibits reduced affinity for A2B receptors (Ki = 67 nM), but offers greater selectivity over A1R (Ki = 290 nM) and A3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington's disease. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number119137
          Brand Family Calbiochem®
          SynonymsCGS-21680, CGS21680, 3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanoic acid
          References
          ReferencesWillians, A. J., et al. 2012. Inflammation. 35, 614.
          Mazzon, E. et al. 2011. J Rheumatol. 38, 2119,
          Martire, A., et al. 2007. Neurosci Lett. 417, 78.
          Chou, S. Y., et al, 2005. Journ Neurochem. 93, 310.
          Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol.362 382.
          Phillis, J. W., et al. 1990.Brain Res. 509, 328.
          Product Information
          CAS number124182-57-6
          FormWhite solid
          FormulationSupplied as a hydrochloride salt.
          Hill FormulaC₂₃H₂₉N₇O₆ • HCl
          Chemical formulaC₂₃H₂₉N₇O₆ • HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          119137

          References

          Reference overview
          Willians, A. J., et al. 2012. Inflammation. 35, 614.
          Mazzon, E. et al. 2011. J Rheumatol. 38, 2119,
          Martire, A., et al. 2007. Neurosci Lett. 417, 78.
          Chou, S. Y., et al, 2005. Journ Neurochem. 93, 310.
          Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol.362 382.
          Phillis, J. W., et al. 1990.Brain Res. 509, 328.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-March-2013 JSW
          SynonymsCGS-21680, CGS21680, 3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanoic acid
          DescriptionA xanthin derivative that acts as a potent agonist of adenosine A2A receptors (Ki = 27 nM). Exhibits reduced affinity for A2B receptors (Ki = 67 nM), but offers greater selectivity over A1R (Ki = 290 nM) and A3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington's disease.
          FormWhite solid
          FormulationSupplied as a hydrochloride salt.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number124182-57-6
          Chemical formulaC₂₃H₂₉N₇O₆ • HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mM)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesWillians, A. J., et al. 2012. Inflammation. 35, 614.
          Mazzon, E. et al. 2011. J Rheumatol. 38, 2119,
          Martire, A., et al. 2007. Neurosci Lett. 417, 78.
          Chou, S. Y., et al, 2005. Journ Neurochem. 93, 310.
          Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol.362 382.
          Phillis, J. W., et al. 1990.Brain Res. 509, 328.