119148 Adenosine A1 Receptor Antagonist II, PSB-36 - CAS 524944-72-7 - Calbiochem

119148
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₃₀N₄O₃ 524944-72-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      119148-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA xanthine derivative that acts as a highly potent and selective antagonist of adenosine A1 receptor (A1R; Ki = 124 pM for rat A1R and 700 pM for human A1R). Exhibits much reduced effect on A2A, A2B, and A3 receptors (Ki = 980, 187, and 2300 nM, respectively). Shown to be more potent than DPCPX (EC50 = 120 pM vs 2.9 nM). Exhibits anti-inflammatory and analgesic effects through a central mechanism. Also reported to modulate insulin release in INS-1 cells.
          Catalogue Number119148
          Brand Family Calbiochem®
          Synonyms1-butyl-3-(3-hydroxypropyl)-8-(3-noradamantyl)xanthine, PSB36, PSB-36, PSB 36
          References
          ReferencesBilkei-Gorzo, A., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 377, 65.
          Weyler, S., et al. 2006. ChemMedChem. 1, 891.
          Tupfer, M., et al. 2008. Cell Biochem. 25, 833.
          Product Information
          CAS number524944-72-7
          FormTan powder
          Hill FormulaC₂₁H₃₀N₄O₃
          Chemical formulaC₂₁H₃₀N₄O₃
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          119148

          References

          Reference overview
          Bilkei-Gorzo, A., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 377, 65.
          Weyler, S., et al. 2006. ChemMedChem. 1, 891.
          Tupfer, M., et al. 2008. Cell Biochem. 25, 833.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2014 JSW
          Synonyms1-butyl-3-(3-hydroxypropyl)-8-(3-noradamantyl)xanthine, PSB36, PSB-36, PSB 36
          DescriptionA xanthine derivative that acts as a highly potent and selective antagonist of adenosine A1 receptor (A1R; Ki = 124 pM for rat A1R and 700 pM for human A1R). Exhibits much reduced effect on A2A, A2B, and A3 receptors (Ki = 980, 187, and 2300 nM, respectively). Shown to be more potent than DPCPX (EC50 = 120 pM vs 2.9 nM). Exhibits anti-inflammatory and analgesic effects through a central mechanism. Also reported to modulate insulin release in INS-1 cells.
          FormTan powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number524944-72-7
          Chemical formulaC₂₁H₃₀N₄O₃
          Purity≥98% by HPLC
          SolubilityDMSO (20 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBilkei-Gorzo, A., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 377, 65.
          Weyler, S., et al. 2006. ChemMedChem. 1, 891.
          Tupfer, M., et al. 2008. Cell Biochem. 25, 833.