28745 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem

28745
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₂₃N₅O₈P · Na 16980-89-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      28745-100MG
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          Plastic ampoule 100 mg
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          28745-25MG
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              Description
              OverviewA cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
              Catalogue Number28745
              Brand Family Calbiochem®
              SynonymsDibutyryl-cAMP, Na
              References
              ReferencesNoveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
              Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
              Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
              Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
              Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
              Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
              Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
              Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
              Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.
              Product Information
              CAS number16980-89-5
              ATP CompetitiveN
              FormWhite lyophilized solid
              Hill FormulaC₁₈H₂₃N₅O₈P · Na
              Chemical formulaC₁₈H₂₃N₅O₈P · Na
              Hygroscopic Hygroscopic
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetPKA
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSES5055500
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions are stable for up to 3 days at 4°C or for up to 3 months at -20°C. Avoid pH >8.5.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              28745

              References

              Reference overview
              Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
              Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
              Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
              Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
              Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
              Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
              Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
              Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
              Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.

              Brochure

              Title
              Nucleotides and Bases Technical Bulletin
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision11-March-2008 JSW
              SynonymsDibutyryl-cAMP, Na
              DescriptionCell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Known to cause an increase in the steady state level of the parathyroid hormone related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
              FormWhite lyophilized solid
              CAS number16980-89-5
              RTECSES5055500
              Chemical formulaC₁₈H₂₃N₅O₈P · Na
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityH₂O (1 mg/ml)
              Storage -20°C
              Hygroscopic
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions are stable for up to 3 days at 4°C or for up to 3 months at -20°C. Avoid pH >8.5.
              Toxicity Standard Handling
              ReferencesNoveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
              Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
              Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
              Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
              Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
              Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
              Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
              Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
              Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.