12-379 Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate

12-379
50 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsEntrez Gene NumberModificationsUni Prot Number
      IP, APA NM_003538.3 Acetylation P62805
      Description
      Catalogue Number12-379
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAcetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate
      OverviewSynthetic peptide, containing amino acids 1-18 of Histone H4 followed by a GSGS linker and biotinylated lysine (SGRGACKGGACKGLGAC-KGGAACKRHGSGSK-biotin).
      References
      Product Information
      PresentationLyophilized powder
      Applications
      ApplicationAcetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate primarily used in Immunoprecipitation and Affinity Precipitation Assays.
      Key Applications
      • Immunoprecipitation
      • Affinity Precipitation Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
      Gene Symbol
      • HIST1H4A
      • H4/J
      • HIST1H4F
      • HIST1H4L
      • H4FN
      • H4FA
      • H4FH
      • HIST1H4H
      • H4F2
      • H4FM
      • H4/A
      • H4FK
      • H4FG
      • HIST2H4
      • H4FB
      • H4/K
      • HIST1H4I
      • H4/N
      • HIST1H4B
      • H4FE
      • H4/M
      • H4/a
      • HIST1H4E
      • HIST4H4
      • HIST2H4A
      • H4FC
      • H4FI
      • H4/H
      • HIST1H4C
      • H4/G
      • HIST1H4K
      • H4FJ
      • H4FD
      • H4/I
      • H4/B
      • H4/D
      • H4/C
      • HIST1H4J
      • HIST1H4D
      • H4/E
      Modifications
      • Acetylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
      SIZE: 103 amino acids; 11367 Da
      SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
      SUBCELLULAR LOCATION: Nucleus.
      PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
      SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated in a kinase assay using MAPKAP Kinase 2, active (Catalog # 14-216 & 14-337) to phosphorylate the substrate peptide.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate SDS

      Title

      Safety Data Sheet (SDS) 

      Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate Certificates of Analysis

      TitleLot Number
      Acetyl-Histone H4 (Lys5, 8, 12, 16) - DAM1487565DAM1487565
      Acetyl-Histone H4 (Lys5, 8, 12, 16) - DAM1787883DAM1787883
      Acetyl-Histone H4 (Lys5, 8, 12, 16) - DAM1821160DAM1821160
      Acetyl-Histone H4 (Lys5, 8, 12, 16) - JBC1863379JBC1863379
      Acetyl-Histone H4 (Lys5, 8, 12, 16) -12-37912-379
      Acetyl-Histone H4 (Lys5, 8, 12, 16) -26591482659148
      Acetyl-Histone H4 (Lys5, 8, 12, 16) -27123032712303
      Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate3037907
      Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate3090006
      Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate - 1954819548

      References

      Reference overviewPub Med ID
      Screening, identification, and characterization of mechanistically diverse inhibitors of the Mycobacterium tuberculosis enzyme, pantothenate kinase (CoaA).
      Janani Venkatraman,Jyothi Bhat,Suresh M Solapure,Jatheendranath Sandesh,Debasmita Sarkar,Sundaram Aishwarya,Kakoli Mukherjee,Santanu Datta,Krishnan Malolanarasimhan,Balachandra Bandodkar,Kaveri S Das
      Journal of biomolecular screening  17  2012

      Show Abstract
      22086722 22086722

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      Alternative Format

      Catalog Number Description  
      12-353 Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Control Histones