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12-346 | Acetyl-Histone H4 (Lys16) Peptide

100 µg  
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      Replacement Information

      Key Specifications Table

      Key ApplicationsEntrez Gene NumberModificationsUni Prot Number
      HAT, WB NM_003538.3 Acetylation P62805
      Catalogue Number12-346
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAcetyl-Histone H4 (Lys16) Peptide
      Product Information
      Presentationsterile deionized water
      ApplicationAcetyl-Histone H4 (Lys16) Peptide primarily used in Histone Acetyltransferase Assays (HAT) and Western Blotting.
      Key Applications
      • Histone Acetyltransferase Assay (HAT)
      • Western Blotting
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
      Gene Symbol
      • HIST1H4A
      • H4/J
      • HIST1H4F
      • HIST1H4L
      • H4FN
      • H4FA
      • H4FH
      • HIST1H4H
      • H4F2
      • H4FM
      • H4/A
      • H4FK
      • H4FG
      • HIST2H4
      • H4FB
      • H4/K
      • HIST1H4I
      • H4/N
      • HIST1H4B
      • H4FE
      • H4/M
      • H4/a
      • HIST1H4E
      • HIST4H4
      • HIST2H4A
      • H4FC
      • H4FI
      • H4/H
      • HIST1H4C
      • H4/G
      • HIST1H4K
      • H4FJ
      • H4FD
      • H4/I
      • H4/B
      • H4/D
      • H4/C
      • HIST1H4J
      • HIST1H4D
      • H4/E
      • Acetylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
      SIZE: 103 amino acids; 11367 Da
      SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
      PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
      SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Immunoblot Analysis. This peptide can be used as a standard for antibodies specific for acetylation of lysine 16 of histone H4.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Acetyl-Histone H4 (Lys16) Peptide (substrate for HAT activity) - 2435049 2435049
      Acetyl-Histone H4 (Lys16) Peptide (substrate for HAT activity) - 2227359 2227359
      Acetyl-Histone H4 (Lys16) Peptide (substrate for HAT activity) - 2301394 2301394
      Acetyl-Histone H4 (Lys16) Peptide (substrate for HAT activity) -2505159 2505159
      Acetyl-Histone H4 (Lys16) Peptide - 16453 16453
      Acetyl-Histone H4 (Lys16) Peptide - 2032850 2032850
      Acetyl-Histone H4 (Lys16) Peptide - 20552 20552
      Acetyl-Histone H4 (Lys16) Peptide - 30292 30292
      Acetyl-Histone H4 (Lys16) Peptide - 31507 31507
      Acetyl-Histone H4 (Lys16) Peptide - JBC1371265 JBC1371265
      Acetyl-Histone H4 (Lys16) Peptide - JBC1873447 JBC1873447
      Acetyl-Histone H4 (Lys16) Peptide - JBC1922557 JBC1922557


      Reference overviewPub Med ID
      The TAF(II)250 subunit of TFIID has histone acetyltransferase activity.
      Mizzen, C A, et al.
      Cell, 87: 1261-70 (1996) 1996

      Show Abstract
      8980232 8980232

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      Product Families


      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Control Histones