A part of MilliporeSigma

14-757M | Abl (M351T) Protein, active, 250 µg

250 µg  Also available in 10 μg size (cat#14-757) and in bulk (cat#14-757-K).
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
Limited Quantities Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service


      Contact Customer Service

      Click To Print This Page


      Replacement Information
      Catalogue Number14-757M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAbl (M351T) Protein, active, 250 µg
      OverviewThe Abl tyrosine kinase inhibitor STI571 is an effective therapy for stable-phase chronic myeloid leukemia patients. Many patients responding to STI571 later relapse due to a reactivation of Bcr-Abl activity. In certain cases this appears to correlate with the presence of the M351T mutation, which confers resistance to drug binding (Shah et al., (2002), Cancer Cell 2, 117-125).
      Product Information
      Presentation50mM Tris/HCl pH7.5, 150mM NaCl, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.03% Brij 35. Frozen solution.
      ApplicationActive, N-terminal 6His-tagged recombinant human Abl, residues 27-end containing the M351T mutation. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceN-terminal 6His-tagged recombinant human Abl, residues 27-end containing the M351T mutation. Expressed by baculovirus in Sf21 insect cells.
      Entrez Gene Number
      Gene Symbol
      • ABL1
      • JTK7
      • ABL
      • p150
      • vABL
      • cABL
      • bcr/abl
      Protein TargetAbl
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      Molecular Weight121 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of Abltide.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore -70°C. For maximum recovery of product, centrifuge original vial prior to removing the cap.
      Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-757) and in bulk (cat#14-757-K).
      Transport Information
      Supplemental Information


      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-757 Abl (M351T) Protein, active, 10 µg Show Pricing & Availability

      Product Families


      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases