118500 | ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem

118500
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₁₇NO₃S₂ 587871-26-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      118500-10MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 10 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          118500-2MG
          Retrieving availability...
          Limited AvailabilityLimited Availability
          Stocked 
          Discontinued
          Limited Quantities Available
          Available
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service

              Glass bottle 2 mg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity needs to be mulitiple of
              Upon Order Completion More Information
              You Saved ()
               
              Request Pricing
              Description
              OverviewA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5 , 9.3 , 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 = µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents. A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118502) in DMSO is also available.
              Catalogue Number118500
              Brand Family Calbiochem®
              Synonyms2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
              References
              ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
              Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
              Hickson, I., et al. 2004. Cancer Res. 64, 9152.
              Product Information
              CAS number587871-26-9
              ATP CompetitiveY
              FormWhite solid
              Hill FormulaC₂₁H₁₇NO₃S₂
              Chemical formulaC₂₁H₁₇NO₃S₂
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetATM Kinase
              Primary Target IC<sub>50</sub>13 nM
              Primary Target K<sub>i</sub>2.2 nM for ATM kinase
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Shipped with Blue Ice or with Dry Ice
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              118500

              References

              Reference overview
              Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
              Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
              Hickson, I., et al. 2004. Cancer Res. 64, 9152.

              Brochure

              Title
              Biologics 33.1 ( 1.37 MB )
              New Research Tools for Signal Transduction and Life Science Research
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision06-February-2014 JSW
              Synonyms2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
              DescriptionA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.
              FormWhite solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number587871-26-9
              Chemical formulaC₂₁H₁₇NO₃S₂
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMSO (4 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Toxicity Standard Handling
              ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
              Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
              Hickson, I., et al. 2004. Cancer Res. 64, 9152.