118501 ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem

118501
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₁₈Cl₃FN₄O₃S 905973-89-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      118501-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable thiourea compound that selectively inhibits the kinase activity of ATM and ATR (IC50 = ~200 nM) without significant effect against other PIKK family members (PI 3-K, mTOR, and DNA-PK) or kinases that are known to phosphorylate p53 (ERK, CK1, Cdk2, JNK, PKC, CAK, Chk1, PKR, and p38). Shown to reverse senescence in human primary BJ and HMEC cells. Unlike LY 294002 (Cat. No. 440202 and 440204), this inhibitor does not interfere with cellular PI 3-K/PDK1/Akt signaling pathway.
          Catalogue Number118501
          Brand Family Calbiochem®
          SynonymsCGK 733
          References
          ReferencesGoldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. in press.
          Crescenzi, E., et al. 2008. Clin. Cancer Res. 14, 1877.
          Cruet-Hennequart, S., et al. 2008. DNA Repair 7, 582.
          Won, J., et al. 2006. Nat. Chem. Biol. 2, 369. (RETRACTED)
          Product Information
          CAS number905973-89-9
          ATP CompetitiveN
          FormPale yellow solid
          Hill FormulaC₂₃H₁₈Cl₃FN₄O₃S
          Chemical formulaC₂₃H₁₈Cl₃FN₄O₃S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetATM/ATR
          Primary Target IC<sub>50</sub>~200 nM against ATM and ATR
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          118501

          References

          Reference overview
          Goldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. in press.
          Crescenzi, E., et al. 2008. Clin. Cancer Res. 14, 1877.
          Cruet-Hennequart, S., et al. 2008. DNA Repair 7, 582.
          Won, J., et al. 2006. Nat. Chem. Biol. 2, 369. (RETRACTED)

          Brochure

          Title
          Biologics 33.1 ( 1.37 MB )
          New Research Tools for Signal Transduction and Life Science Research
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-June-2008 JSW
          SynonymsCGK 733
          DescriptionA cell-permeable thiourea compound that selectively inhibits the kinase activity of ATM and ATR (IC50 ~ 200 nM) without significant effect against other PIKK family members (PI3K, mTOR, and DNA-PK) or kinases that are known to phosphorylate p53 (ERK, CK1, Cdk2, JNK, PKC, CAK, Chk1, PKR, and p38). Shown to reverse senescence in human primary BJ and HMEC cells. Unlike LY 294002 (Cat. No. 440202 and 440204), this inhibitor does not interfere with cellular PI3K-PDK1-Akt signaling pathway.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number905973-89-9
          Chemical formulaC₂₃H₁₈Cl₃FN₄O₃S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesGoldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. in press.
          Crescenzi, E., et al. 2008. Clin. Cancer Res. 14, 1877.
          Cruet-Hennequart, S., et al. 2008. DNA Repair 7, 582.
          Won, J., et al. 2006. Nat. Chem. Biol. 2, 369. (RETRACTED)