531620 APT1 Inhibitor II, Cpd21 - Calbiochem

531620
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₈H₁₇ClF₃N₃O₃

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      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.31620.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300 nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA1 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531620
          Brand Family Calbiochem®
          SynonymsLYPLA1 Inhibitor, Lysophospholipase Inhibitor
          References
          ReferencesAdibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.
          Product Information
          FormWhite solid
          Hill FormulaC₁₈H₁₇ClF₃N₃O₃
          Chemical formulaC₁₈H₁₇ClF₃N₃O₃
          ReversibleY
          Applications
          Biological Information
          Primary TargetAPT1
          Primary Target IC<sub>50</sub>840 nM, Ki
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          APT1 Inhibitor II, Cpd21 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Adibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.

          Brochure

          Title
          NPI Flyer- Epigenetics and Nuclear Function Feature (EMD)
          New Products - Antibodies, Small Molecule, Inhibitors

          Technical Info

          Title
          White Paper: Further considerations of antibody validation and usage. (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-December-2014
          SynonymsLYPLA1 Inhibitor, Lysophospholipase Inhibitor
          DescriptionA cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300 nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA1 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₈H₁₇ClF₃N₃O₃
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAdibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.