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208719 | ALLN - CAS 110044-82-1 - Calbiochem

208719
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₃₇N₃O₄ 110044-82-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208719-25MG
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          Glass bottle 25 mg
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          208719-5MG
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              Glass bottle 5 mg
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              Description
              OverviewCell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Modulates the processing of the β-amyloid precursor protein (βAPP) to β-amyloid (Aβ). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also inhibits reovirus-induced apoptosis in L929 cells. Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208750) in DMSO is also available.
              Catalogue Number208719
              Brand Family Calbiochem®
              SynonymsLLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
              References
              ReferencesDebiasi, R.L., et al. 1999. J. Virol. 73, 695.
              Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
              Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
              Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
              Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
              Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
              Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
              Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
              Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
              Product Information
              CAS number110044-82-1
              ATP CompetitiveN
              FormWhite to off-white solid
              Hill FormulaC₂₀H₃₇N₃O₄
              Chemical formulaC₂₀H₃₇N₃O₄
              ReversibleN
              Structure formula Image
              Applications
              ApplicationALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
              Biological Information
              Primary TargetCalpain-1
              Primary Target K<sub>i</sub>190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Peptide SequenceN-Acetyl-Leu-Leu-Nle-CHO
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              208719

              References

              Reference overview
              Debiasi, R.L., et al. 1999. J. Virol. 73, 695.
              Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
              Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
              Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
              Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
              Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
              Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
              Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
              Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.

              Brochure

              Title
              Protease and Phosphatase Inhibitor Cocktails Brochure
              Proteasomes Technical Bulletin

              Citations

              Title
            • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision03-October-2007 RFH
              SynonymsLLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
              DescriptionInhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and proteasome (Ki = 6 µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex.
              FormWhite to off-white solid
              CAS number110044-82-1
              Chemical formulaC₂₀H₃₇N₃O₄
              Peptide SequenceN-Acetyl-Leu-Leu-Nle-CHO
              Structure formula
              Purity≥95% by HPLC
              SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
              Storage +2°C to +8°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesDebiasi, R.L., et al. 1999. J. Virol. 73, 695.
              Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
              Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
              Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
              Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
              Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
              Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
              Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
              Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
              Citation
            • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
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              Categories

              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors
              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors
              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Proteasome and Ubiquitination Pathway Inhibitors