531170 ALDH3A1 Inhibitor, CB29 - Calbiochem

531170
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₅H₁₅N₃O₅S

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      5.31170.0001
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          Glass bottle 25 mg
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          Description
          OverviewA cell permeable diarylamine derivative that acts as a selective, reversible, substrate-binding site directed inhibitor of aldehyde dehydrogenase ALDH3A1 (Ki = 4.7 µM, IC50 = 16 µM). Does not inhibit the activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, and ALDH2 even at higher concentrations (250 µM). Shown to significantly reduce the activity of ALDH3A1 in A549 and SF767 cell lysates, but does not affect CCD-13Lu cells that lack ALDH3A1 activity. Although it does not affect tumor cell proliferation, it significantly improves the sensitivity of cancer cells to mafosfamide.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531170
          Brand Family Calbiochem®
          SynonymsAldehyde dehydrogenase ALDH3A1 inhibitor, CB29
          References
          ReferencesParajuli, B. et al. 2014. Chembiochem. 15, 701.
          Product Information
          FormYellow powder
          Hill FormulaC₁₅H₁₅N₃O₅S
          Chemical formulaC₁₅H₁₅N₃O₅S
          ReversibleY
          Applications
          Biological Information
          Primary TargetALDH3A1
          Primary Target K<sub>i</sub>4.7 µ
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          ALDH3A1 Inhibitor, CB29 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Parajuli, B. et al. 2014. Chembiochem. 15, 701.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-August-2014 JSW
          SynonymsAldehyde dehydrogenase ALDH3A1 inhibitor, CB29
          DescriptionA cell permeable diarylamine derivative that acts as a selective, reversible, substrate-binding site directed inhibitor of aldehyde dehydrogenase ALDH3A1 (Ki = 4.7 µM, IC50 = 16 µM). Does not inhibit the activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, and ALDH2 even at higher concentrations (250 µM). Shown to significantly reduce the activity of ALDH3A1 in A549 and SF767 cell lysates, but does not affect CCD-13Lu cells that lack ALDH3A1 activity. Although it does not affect tumor cell proliferation, it significantly improves the sensitivity of cancer cells to mafosfamide.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₅H₁₅N₃O₅S
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesParajuli, B. et al. 2014. Chembiochem. 15, 701.