123040 | AICA-Riboside - CAS 2627-69-2 - Calbiochem

123040
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₁₄N₄O₅ 2627-69-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      123040-50MG
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          Plastic ampoule 50 mg
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          Description
          OverviewA cell-permeable nucleoside compound whose phosphorylated metabolite activates adenosine monophosphate-activated protein kinase (AMPK) and acts as a regulator of de novo purine synthesis. Stimulates glucose uptake in perfused and isolated muscle. Offers protection against cell death induced by glucose deprivation, chemical hypoxia, and exposure to glutamate and Aβ peptide.
          Catalogue Number123040
          Brand Family Calbiochem®
          SynonymsAcadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-riboside, Z-Riboside, AMPK Signaling Activator II
          References
          ReferencesMeli, M., et al. 2006. J. Med. Chem. in press.
          Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45.
          Muoio, D.M., et al. 1999. Biochem. J. 338, 783.
          Hayashi, T., et al. 1998. Diabetes 47, 1369.
          Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.
          Product Information
          CAS number2627-69-2
          ATP CompetitiveN
          FormTan solid
          Hill FormulaC₉H₁₄N₄O₅
          Chemical formulaC₉H₁₄N₄O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAdenosine monophosphate-activated protein kinase (AMPK)
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          123040

          References

          Reference overview
          Meli, M., et al. 2006. J. Med. Chem. in press.
          Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45.
          Muoio, D.M., et al. 1999. Biochem. J. 338, 783.
          Hayashi, T., et al. 1998. Diabetes 47, 1369.
          Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.

          Brochure

          Title
          Calbiochem Biologics 32.2
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-April-2008 RFH
          SynonymsAcadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-riboside, Z-Riboside, AMPK Signaling Activator II
          DescriptionA cell-permeable nucleoside compound that is processed intracellularly to form a phosphorylated metabolite, which activates adenosine monophosphate-activated protein kinase (AMPK) without disrupting the cellular concentrations of ATP, ADP, or AMP. Also acts as a regulator of de novo purine synthesis. Stimulates glucose uptake in both perfused and isolated muscle. AICAr-stimulated glucose transport is not affected by Wortmannin (Cat. No. 681675), a PI-3K inhibitor. Shown to inhibit the synthesis of triacylglycerol (TAG), diacylglycerol (DAG), and phospholipid, probably as a result of AMPK activation and the subsequent inhibition of sn-glycerol-3-phosphate acyltransferase (GPAT) by AMPK. Also reported to inhibit Hsp90 chaperone function. Imparts protection against cell death induced by glucose deprivation, chemical hypoxia, and exposure to glutamate and amyloid β (Aβ) peptide.
          FormTan solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number2627-69-2
          Chemical formulaC₉H₁₄N₄O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityMethanol (10 mg/ml) or H₂O. May require heating to 50°C to achieve complete solubilization in methanol.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMeli, M., et al. 2006. J. Med. Chem. in press.
          Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45.
          Muoio, D.M., et al. 1999. Biochem. J. 338, 783.
          Hayashi, T., et al. 1998. Diabetes 47, 1369.
          Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.