121765 | AG 825 - CAS 149092-50-2 - Calbiochem

121765
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₅N₃O₃S₂ 149092-50-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      121765-2MG
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          Plastic ampoule 2 mg
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          Description
          OverviewA potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC50 = 0.35 µM) relative to HER1 (IC50 = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu.
          Catalogue Number121765
          Brand Family Calbiochem®
          Synonyms4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide
          References
          ReferencesAshton, J.M., et al. 2012. Cell Stem Cell 11, 359.
          Tsai, C.M., et al. 1996. Cancer Res. 56, 1068.
          Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
          Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.
          Product Information
          CAS number149092-50-2
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₉H₁₅N₃O₃S₂
          Chemical formulaC₁₉H₁₅N₃O₃S₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetHER2
          Primary Target IC<sub>50</sub>0.35 µM against HER2
          Purity≥94% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          121765

          References

          Reference overview
          Ashton, J.M., et al. 2012. Cell Stem Cell 11, 359.
          Tsai, C.M., et al. 1996. Cancer Res. 56, 1068.
          Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
          Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-March-2015 JSW
          Synonyms4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide
          DescriptionA potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER-2 (neu/erbB-2, IC50 = 0.35 µM) relative to HER-1 (IC50 = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances the chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu.
          FormYellow solid
          CAS number149092-50-2
          Chemical formulaC₁₉H₁₅N₃O₃S₂
          Structure formulaStructure formula
          Purity≥94% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAshton, J.M., et al. 2012. Cell Stem Cell 11, 359.
          Tsai, C.M., et al. 1996. Cancer Res. 56, 1068.
          Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
          Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.