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658395 | AG 18 - CAS 118409-57-7 - Calbiochem

658395
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₆N₂O₂ 118409-57-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      658395-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA broad-spectrum protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to Angiotensin II (Cat. No. 05-23-0101). Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini.
          Catalogue Number658395
          Brand Family Calbiochem®
          Synonymsα-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810
          References
          ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
          Kapas, S., et al. 1995. Biochem. J. 305, 433.
          Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
          Williams, J.A. 1994. Am. J. Physiol. 267, G401.
          Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
          Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
          Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
          Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.
          Product Information
          CAS number118409-57-7
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₀H₆N₂O₂
          Chemical formulaC₁₀H₆N₂O₂
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary Targetepidermal growth factor receptor autophosphorylation
          Primary Target IC<sub>50</sub>40 µM against epidermal growth factor receptor autophosphorylation; 10 µM against GTPase activity of transducin
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          658395

          References

          Reference overview
          Jaleel, M., et al. 2004. Biochemistry 43, 8247.
          Kapas, S., et al. 1995. Biochem. J. 305, 433.
          Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
          Williams, J.A. 1994. Am. J. Physiol. 267, G401.
          Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
          Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
          Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
          Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-May-2011 RFH
          Synonymsα-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810
          DescriptionA cell-permeable, reversible, substrate competitive protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to angiotensin II. Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini. Also reported to inhibit guanylyl cyclase.
          FormYellow solid
          CAS number118409-57-7
          Chemical formulaC₁₀H₆N₂O₂
          Structure formula
          Purity≥98% by HPLC
          SolubilityAcetic acid, DMSO (100 mg/ml), or ethanol (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
          Kapas, S., et al. 1995. Biochem. J. 305, 433.
          Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
          Williams, J.A. 1994. Am. J. Physiol. 267, G401.
          Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
          Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
          Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
          Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.