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658452 | AG 126 - CAS 118409-62-4 - Calbiochem

658452
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₅N₃O₃ 118409-62-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      658452-5MG
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          Alu drum 5 mg
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          Description
          OverviewA cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 15.38 µM).
          Catalogue Number658452
          Brand Family Calbiochem®
          Synonymsα-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
          References
          ReferencesCuzzocrea, S., et al. 2000. Am. J. Pathol. 157, 145.
          Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138.
          Kan, H., et al. 1996. Mol. Pharmacol. 50, 1139.
          Novogrodsky, A., et al. 1994. Science 264, 1319.
          Product Information
          CAS number118409-62-4
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₀H₅N₃O₃
          Chemical formulaC₁₀H₅N₃O₃
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetCOX-2 activity
          Primary Target IC<sub>50</sub>15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 23/24/25

          Toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          658452

          References

          Reference overview
          Cuzzocrea, S., et al. 2000. Am. J. Pathol. 157, 145.
          Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138.
          Kan, H., et al. 1996. Mol. Pharmacol. 50, 1139.
          Novogrodsky, A., et al. 1994. Science 264, 1319.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-January-2010 RFH
          Synonymsα-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
          DescriptionA cell-permeable inhibitor of lipopolysaccaride (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK protein substrate.
          FormYellow solid
          CAS number118409-62-4
          Chemical formulaC₁₀H₅N₃O₃
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMF or DMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Toxic
          ReferencesCuzzocrea, S., et al. 2000. Am. J. Pathol. 157, 145.
          Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138.
          Kan, H., et al. 1996. Mol. Pharmacol. 50, 1139.
          Novogrodsky, A., et al. 1994. Science 264, 1319.