A part of MilliporeSigma

114810 | ADAMTS-5 Inhibitor - CAS 929634-33-3 - Calbiochem

114810
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₁ClF₃N₃OS₃ 929634-33-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      114810-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA thioxothiazolidinone compound that possesses a Zn2+-chelating structural motif and acts as an ADAMTS-5 (aggrecanase-2) inhibitor (IC50 = 1.1 µM) with ~40-fold selectivity over ADAMTS-4 (aggrecanase-1).
          Catalogue Number114810
          Brand Family Calbiochem®
          Synonyms5-((4-Chlorobenzylthio-3-trifluoromethyl-N-methyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, Aggrecanase-2 Inhibitor
          References
          ReferencesBursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1185.
          Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1189.
          Product Information
          CAS number929634-33-3
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₆H₁₁ClF₃N₃OS₃
          Chemical formulaC₁₆H₁₁ClF₃N₃OS₃
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetADAMTS-5
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22-36/37/38

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 36/37

          Wear suitable protective clothing and gloves.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          114810

          References

          Reference overview
          Bursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1185.
          Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1189.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-April-2011 RFH
          Synonyms5-((4-Chlorobenzylthio-3-trifluoromethyl-N-methyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, Aggrecanase-2 Inhibitor
          DescriptionA thioxothiazolidinone compound that possesses a Zn2+-chelating structural motif and acts as an ADAMTS-5 (aggrecanase-2) inhibitor (IC50 = 1.1 µM) with ~40-fold selectivity over ADAMTS-4 (aggrecanase-1).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number929634-33-3
          Chemical formulaC₁₆H₁₁ClF₃N₃OS₃
          Structure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesBursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1185.
          Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1189.