534349 ABHD16A Inhibitor, KC01 - Calbiochem

534349
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₃₉NO₃

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.34349.0001
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable beta-lactone based compound that acts as a potent, selective, and covalent inhibitor of phosphatidylserine (PS) lipase ABHD16A (BAT5, IC50 = 90 and 520 nM for human and mouse ABHD16A, respectively). Displays reduced effect on ~60 other serine hydrolases profiled. Shown to block the PS lipase activity of membrane fractions from COLO205, K562 and MCF7 cell lines and is also shown to diminish the PS lipase activity of brain membrane lysates from Abhd12+/+ (IC50 = 290 nM) and Abhd12-/- (IC50 = 340 nM) mice. Significantly reduces lysophosphatidylserine (lyso-PSs) levels in cells, without affecting the levels of other lipids, such as phosphatidylcholine (PC), phosphatidylethano-lamines (PE), lyso-PCs, lyso-PEs or monoacylglycerols. Blunts lipopolysaccharide-induce release of IL-6, IL-1β in mouse macrophages.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number534349
          Brand Family Calbiochem®
          Synonyms(Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide, BAT5 Inhibitor, KC01
          References
          ReferencesKamat, S., et al. 2015. Nat. Chem. Biol. 11, 164.
          Product Information
          FormOff-white solid
          Hill FormulaC₂₂H₃₉NO₃
          Chemical formulaC₂₂H₃₉NO₃
          Applications
          Biological Information
          Primary TargetABHD16A
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          ABHD16A Inhibitor, KC01 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Kamat, S., et al. 2015. Nat. Chem. Biol. 11, 164.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-March-2017 JSW
          Synonyms(Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide, BAT5 Inhibitor, KC01
          DescriptionA cell-permeable beta-lactone based compound that acts as a potent, selective, and covalent inhibitor of phosphatidylserine (PS) lipase ABHD16A (BAT5, IC50 = 90 and 520 nM for human and mouse ABHD16A, respectively). Displays reduced effect on ~60 other serine hydrolases profiled. Shown to block the PS lipase activity of membrane fractions from COLO205, K562 and MCF7 cell lines and is also shown to diminish the PS lipase activity of brain membrane lysates from Abhd12+/+ (IC50 = 290 nM) and Abhd12-/- (IC50 = 340 nM) mice. Significantly reduces lysophosphatidylserine (lyso-PSs) levels in cells, without affecting the levels of other lipids, such as phosphatidylcholine (PC), phosphatidylethano-lamines (PE), lyso-PCs, lyso-PEs or monoacylglycerols. Blunts lipopolysaccharide-induce release of IL-6, IL-1β in mouse macrophages.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₃₉NO₃
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKamat, S., et al. 2015. Nat. Chem. Biol. 11, 164.