100110 | AAPH - CAS 2997-92-4 - Calbiochem

100110
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₁₈N₆ · 2HCl 2997-92-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      100110-1GM
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          Glass bottle 1 gm
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          Description
          OverviewA heat-sensitive, water-soluble, free radical initiator that induces oxidative stress by causing cellular damage associated with lipid peroxidation, protein modification, hemoglobin oxidation, and DNA strand breakage. Reported to induce apoptosis in HL-60 cells via activation of caspase-3.
          Catalogue Number100110
          Brand Family Calbiochem®
          SynonymsABAP, 2,2ʹ-Azobis-(2-amidinopropane), 2HCl, 2,2ʹ-Azobis-(2-methylpropionamidine), 2HCl
          References
          ReferencesIshika, R., et al. 2001. J. Biochem. (Tokyo) 129, 35.
          Raneva, V., et al. 2001. Lipids 36, 1111.
          Thomas, M.J., et al. 2001. Biochemistry 40, 1719.
          Kwon, H.Y., et al. 2000. Biochem. Biophys. Acta 1543, 69.
          Bassett, C.N., et al. 1999. Lipids 34, 1273.
          Viner, R.I., et al. 1997. Biochemistry 36, 7706.
          Kanno, T., et al. 1994. Free Radic. Res. 21, 223.
          Product Information
          CAS number2997-92-4
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₈H₁₈N₆ · 2HCl
          Chemical formulaC₈H₁₈N₆ · 2HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationAAPH, CAS 2997-92-4, is a heat-sensitive, water-soluble, free radical initiator. Induces oxidative stress to cause lipid peroxidation, protein modification & DNA strand breakage.
          Biological Information
          Primary TargetFree radical initiator that induces oxidative stress
          Purity≥96% by titration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUE4575500
          Safety Information
          R PhraseR: 20/21/22-36/37/38-42/43

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause sensitization by inhalation and skin contact.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 24 h at 4°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          100110

          References

          Reference overview
          Ishika, R., et al. 2001. J. Biochem. (Tokyo) 129, 35.
          Raneva, V., et al. 2001. Lipids 36, 1111.
          Thomas, M.J., et al. 2001. Biochemistry 40, 1719.
          Kwon, H.Y., et al. 2000. Biochem. Biophys. Acta 1543, 69.
          Bassett, C.N., et al. 1999. Lipids 34, 1273.
          Viner, R.I., et al. 1997. Biochemistry 36, 7706.
          Kanno, T., et al. 1994. Free Radic. Res. 21, 223.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-June-2008 JSW
          SynonymsABAP, 2,2ʹ-Azobis-(2-amidinopropane), 2HCl, 2,2ʹ-Azobis-(2-methylpropionamidine), 2HCl
          DescriptionA heat-sensitive, water-soluble, free radical initiator that induces oxidative stress by causing cellular damage associated with lipid peroxidation, protein modification, hemoglobin oxidation, and DNA strand breakage. Reported to induce apoptosis in HL-60 cells via activation of caspase-3 by lysosomal cysteine proteases. Particularly useful in inducing cell death at hyperthermic temperatures.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number2997-92-4
          RTECSUE4575500
          Chemical formulaC₈H₁₈N₆ · 2HCl
          Structure formulaStructure formula
          Purity≥96% by titration
          SolubilityH₂O (20 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 24 h at 4°C.
          Toxicity Harmful
          ReferencesIshika, R., et al. 2001. J. Biochem. (Tokyo) 129, 35.
          Raneva, V., et al. 2001. Lipids 36, 1111.
          Thomas, M.J., et al. 2001. Biochemistry 40, 1719.
          Kwon, H.Y., et al. 2000. Biochem. Biophys. Acta 1543, 69.
          Bassett, C.N., et al. 1999. Lipids 34, 1273.
          Viner, R.I., et al. 1997. Biochemistry 36, 7706.
          Kanno, T., et al. 1994. Free Radic. Res. 21, 223.