505413 | 5-Iodo-A-85380 dihydrochloride hydrate - CAS 213550-82-4 - Calbiochem

505413
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₁₁IN₂O•2HCl•xH2O 213550-82-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05413.0001
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          Glass bottle 5 mg
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          Description
          OverviewA very potent agonist highly selective for α4β2 and α6β2 nicotinic acetylcholine receptors (nAChR) (Ki= 12 and 10 pM for human and rat α4β2 nAChRs, respectively). An important nAChR ligand for the treatment of pain, smoking addition and other mental disorders.
          Catalogue Number505413
          Brand Family Calbiochem®
          Synonyms3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate, α4β2 and α6β2 Nicotinic Acetylcholine Receptors (nAChR) Agonist, 5-Iodo-A-85380
          References
          ReferencesLiu, X., et al., 2013. Psychopharm. In press.
          Kennett, A., et al., 2012. Nicotine Tob. Res. 14, 1339.
          Huang. LZ, et al., 2011. Neuropharm. 60, 861.
          Mogg. AJ, et al., 2004. Neuropharm. 60, 861.
          Mukhin, A.G., et al., 2000. Mol. Pharmacol. 47, 848.
          Product Information
          CAS number 213550-82-4
          FormOff-white powder
          Hill FormulaC₉H₁₁IN₂O•2HCl•xH2O
          Chemical formulaC₉H₁₁IN₂O•2HCl•xH2O
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetα4β2 nAChR
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Liu, X., et al., 2013. Psychopharm. In press.
          Kennett, A., et al., 2012. Nicotine Tob. Res. 14, 1339.
          Huang. LZ, et al., 2011. Neuropharm. 60, 861.
          Mogg. AJ, et al., 2004. Neuropharm. 60, 861.
          Mukhin, A.G., et al., 2000. Mol. Pharmacol. 47, 848.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-August-2013 JSW
          Synonyms3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate, α4β2 and α6β2 Nicotinic Acetylcholine Receptors (nAChR) Agonist, 5-Iodo-A-85380
          DescriptionA very potent agonist highly selective for α4β2 and α6β2 nicotinic acetylcholine receptors (nAChR) (Ki= 12 and 10 pM for human and rat α4β2 nAChRs, respectively). An important nAChR ligand for the treatment of pain, smoking addition and other mental disorders.
          FormOff-white powder
          CAS number 213550-82-4
          Chemical formulaC₉H₁₁IN₂O•2HCl•xH2O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (22 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLiu, X., et al., 2013. Psychopharm. In press.
          Kennett, A., et al., 2012. Nicotine Tob. Res. 14, 1339.
          Huang. LZ, et al., 2011. Neuropharm. 60, 861.
          Mogg. AJ, et al., 2004. Neuropharm. 60, 861.
          Mukhin, A.G., et al., 2000. Mol. Pharmacol. 47, 848.