260585 | 5ʹ-Deoxy-5ʹ-methylthioadenosine - CAS 2457-80-9 - Calbiochem

260585
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₁H₁₅N₅O₃S 2457-80-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      260585-50MG
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          Plastic ampoule 50 mg
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          Description
          OverviewA cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Potently inhibits the protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also inhibits FGF-2 receptor tyrosine kinase activity as well as the proliferation of human astrocytes and glioma cells.
          Catalogue Number260585
          Brand Family Calbiochem®
          SynonymsMTA, MeSAdo
          References
          ReferencesLee, S.H., and Cho, Y.D. 1998. Exp. Cell Res. 240, 282.
          Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res. 51, 53.
          Joy, A., et al. 1997. Oncogene 14, 171.
          Riscoe, M.K., et al. 1984. Biochem. Pharmacol. 33, 3639.
          Product Information
          CAS number2457-80-9
          FormWhite solid
          Hill FormulaC₁₁H₁₅N₅O₃S
          Chemical formulaC₁₁H₁₅N₅O₃S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetprotein carboxymethyltranferase
          Secondary targetFGF-2receptor tyrosine kinase activity
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSAU7410000
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          260585

          References

          Reference overview
          Lee, S.H., and Cho, Y.D. 1998. Exp. Cell Res. 240, 282.
          Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res. 51, 53.
          Joy, A., et al. 1997. Oncogene 14, 171.
          Riscoe, M.K., et al. 1984. Biochem. Pharmacol. 33, 3639.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-January-2010 RFH
          SynonymsMTA, MeSAdo
          DescriptionA naturally occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). A cell-permeable, reversible, and ATP-competitive inhibitor of protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also acts as an inhibitor of NGF-induced tyrosine phosphorylation in PC12 cells and blocks FGF-2 receptor tyrosine kinase in astrocytes and glioma cells.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number2457-80-9
          RTECSAU7410000
          Chemical formulaC₁₁H₁₅N₅O₃S
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO or DMF (25 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Irritant
          ReferencesLee, S.H., and Cho, Y.D. 1998. Exp. Cell Res. 240, 282.
          Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res. 51, 53.
          Joy, A., et al. 1997. Oncogene 14, 171.
          Riscoe, M.K., et al. 1984. Biochem. Pharmacol. 33, 3639.

          Related Products & Applications

          Categories

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Nucleotides, Nucleosides, Purines, Pyrimidines and Nucleic Acids
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Farnesyltransferase (FTase), Geranylgeranyltransferase (GGTase), & Methyltransferase Inhibitors