504317 | 5-Azacytidine - CAS 320-67-2 - Calbiochem

504317
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₁₂N₄O₅ 320-67-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04317.0001
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          Glass bottle 250 mg
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          Description
          OverviewA cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis. Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage. Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC50 < 4.0 µM). Enhances reprogramming efficiency (EC50 ~ 2.4 µM in iOSKM-MEFs). 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat. No. 189825) & (Cat. No. 189826).
          Catalogue Number504317
          Brand Family Calbiochem®
          Synonyms5'AzaC, 5-Azacitidine, Zcyd, 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
          References
          ReferencesHollenbach, P.W., et al. 2010. PLoS ONE 5, e9001.Nature 454, 49.
          Huangfu, D., et al. 2008. Nat. Biotech. 26, 795.
          Christman, J.K., 2002. Oncogene 21, 5483.
          Product Information
          CAS number320-67-2
          FormOff-white powder
          Hill FormulaC₈H₁₂N₄O₅
          Chemical formulaC₈H₁₂N₄O₅
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDNA & RNA
          Purity≥93% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 45-46

          May cause cancer.
          May cause heritable genetic damage.
          S PhraseS: 22-36/37/39

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsUnstable in H₂O. Following reconstitution, store at 4°C for <12 hr.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Hollenbach, P.W., et al. 2010. PLoS ONE 5, e9001.Nature 454, 49.
          Huangfu, D., et al. 2008. Nat. Biotech. 26, 795.
          Christman, J.K., 2002. Oncogene 21, 5483.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-July-2013 JSW
          Synonyms5'AzaC, 5-Azacitidine, Zcyd, 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
          DescriptionA cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis. Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage. Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC50 < 4.0 µM). Enhances reprogramming efficiency (EC50 ~ 2.4 µM in iOSKM-MEFs). 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat. No. 189825) & (Cat. No. 189826).
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number320-67-2
          Chemical formulaC₈H₁₂N₄O₅
          Structure formulaStructure formula
          Purity≥93% by HPLC
          SolubilityDMSO (100 mg/ml) or H₂O (10 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsUnstable in H₂O. Following reconstitution, store at 4°C for <12 hr.
          Toxicity Toxic & Carcinogenic / Teratogenic
          ReferencesHollenbach, P.W., et al. 2010. PLoS ONE 5, e9001.Nature 454, 49.
          Huangfu, D., et al. 2008. Nat. Biotech. 26, 795.
          Christman, J.K., 2002. Oncogene 21, 5483.