189825 | 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem

189825
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₁₂N₄O₄ 2353-33-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      189825-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. Also available as a 100 mM solution in DMSO (Cat. No. 189826).
          Catalogue Number189825
          Brand Family Calbiochem®
          Synonyms5-Aza-CdR, 5-Aza-dC, 2'-Deoxy-5-azacytidine, Decitabine
          References
          ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
          Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
          Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
          Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
          Haaf, T. 1995. Pharmacol. Ther. 65, 19.
          Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.
          Product Information
          CAS number2353-33-5
          FormLyophilized
          Hill FormulaC₈H₁₂N₄O₄
          Chemical formulaC₈H₁₂N₄O₄
          Structure formula ImageStructure formula Image
          Applications
          Application5-Aza-2ʹ-Deoxycytidine, CAS 2353-33-5, is a cytosine analog that acts as a suicide substrate and inhibits DNA methyltransferase activity.
          Biological Information
          Primary TargetDNA methyltransferase inhibitor
          Purity≥ 98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSXZ3012000
          Safety Information
          R PhraseR: 20/21/22-36/37/38-43-61

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause sensitization by skin contact.
          May cause harm to the unborn child.
          S PhraseS: 22-26-36/37/39-45

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          189825

          References

          Reference overview
          Eggert, A., et al. 2001. Cancer Res. 61, 1314.
          Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
          Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
          Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
          Haaf, T. 1995. Pharmacol. Ther. 65, 19.
          Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.

          Technical Info

          Title
          White Paper - The Message in the Marks: Deciphering Cancer Epigenetics (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-December-2008 JSW
          Synonyms5-Aza-CdR, 5-Aza-dC, 2'-Deoxy-5-azacytidine, Decitabine
          DescriptionA cytosine analog that acts as a DNA methyltransferase inhibitor. Shown to restore mRNA and protein expression of caspase-8 and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) sensitivity of resistant cell lines. Also reported to enhance apoptosis induced by histone deacetylase (HDAC) inhibitors.
          FormLyophilized
          Intert gas (Yes/No) Packaged under inert gas
          CAS number2353-33-5
          RTECSXZ3012000
          Chemical formulaC₈H₁₂N₄O₄
          Structure formulaStructure formula
          Purity≥ 98% by HPLC
          SolubilityDMSO (25 mg/ml), 50% Acetic Acid (25 mg/ml), or Methanol (1 mg/ml) (warming is required to achieve complete solubilization)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
          Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
          Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
          Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
          Haaf, T. 1995. Pharmacol. Ther. 65, 19.
          Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Nucleotides, Nucleosides, Purines, Pyrimidines and Nucleic Acids
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > DNA Methyltransferase Inhibitors