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287891 | 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem

287891
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₁₂Cl₂N₂O₄ 53-85-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      287891-50MG
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          Glass bottle 50 mg
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          Description
          OverviewA potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6 µM). Reported to inhibit insulin-stimulated nuclear and cytosolic p70S6 kinase in CHO cells. Accentuates premature termination of transcription. Has been used to inhibit RNA polymerase II transcription which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes. Induces G1/S cell cycle arrest.
          Catalogue Number287891
          Brand Family Calbiochem®
          Synonyms5,6-Dichlorobenzimidazole Riboside, DRB, Casein Kinase II Inhibitor VII
          References
          ReferencesKim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681.
          Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev. 37, 284.
          Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806.
          Zandomeni, R., et al. 1986. J. Biol. Chem. 261, 3414.
          Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461.
          Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561.
          Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 3167.
          Stewart, M.W., et al. 1977. J. Gen. Virol. 37, 221.
          Product Information
          CAS number53-85-0
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₁₂H₁₂Cl₂N₂O₄
          Chemical formulaC₁₂H₁₂Cl₂N₂O₄
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary Targetcasein kinase II
          Primary Target IC<sub>50</sub>6 µM
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDD7310000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsRoom temperature (+20°C). Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Ethanol stock solutions are stable for up to 6 weeks at 4°C or for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          287891

          References

          Reference overview
          Kim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681.
          Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev. 37, 284.
          Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806.
          Zandomeni, R., et al. 1986. J. Biol. Chem. 261, 3414.
          Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461.
          Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561.
          Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 3167.
          Stewart, M.W., et al. 1977. J. Gen. Virol. 37, 221.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-November-2009 RFH
          Synonyms5,6-Dichlorobenzimidazole Riboside, DRB, Casein Kinase II Inhibitor VII
          DescriptionAccentuates premature termination of transcription close to the promoter. Useful for isolation of RNA sequences near promoter sites that are responsible for mRNA formation. Useful for reversible superinduction of human fibroblast cultures. Potent, ATP-competivie and specific inhibitor of casein kinase II (IC50 = 6 µM). Has been used to inhibit RNA polymerase II transcription, which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes.
          FormWhite solid
          CAS number53-85-0
          RTECSDD7310000
          Chemical formulaC₁₂H₁₂Cl₂N₂O₄
          Structure formula
          Purity≥98% by TLC
          SolubilityDMSO (3 mg/ml) or Ethanol (3 mg/ml). May require warming (47°C) to achieve complete dissolution.
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsRoom temperature (+20°C). Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Ethanol stock solutions are stable for up to 6 weeks at 4°C or for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681.
          Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev. 37, 284.
          Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806.
          Zandomeni, R., et al. 1986. J. Biol. Chem. 261, 3414.
          Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461.
          Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561.
          Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 3167.
          Stewart, M.W., et al. 1977. J. Gen. Virol. 37, 221.