390900 | 4-Hydroxyphenylretinamide - CAS 65646-68-6 - Calbiochem

390900
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₃₃NO₂ 65646-68-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      390900-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity. Active in the prevention and treatment of a variety of neoplasms in animals. Inhibits human breast cancer, prostate adenocarcinoma, and ovarian carcinoma cell proliferation. Inhibits angiogenesis as well as endothelial cell motility and tubule formation. Induces apoptosis in malignant hemopoietic cell lines.
          Catalogue Number390900
          Brand Family Calbiochem®
          SynonymsFenretinide, 4HPR, N-(4-Hydroxyphenyl)-all-trans Retinamide
          References
          ReferencesFormelli, F., et al. 1996. FASEB J. 10, 1014.
          Naik, H.R., et al. 1995. Adv. Pharmacol. 33, 315.
          Delia, D., et al. 1993. Cancer Res. 53, 6036.
          Pienta, K.J., et al. 1993. Cancer Res. 53, 224.
          Grubbs, C.J., et al. 1990. Anticancer Res. 10, 661.
          McCarthy, D.J., et al. 1987. Cancer Res. 47, 5014.
          Moon, R.C., et al. 1979. Cancer Res. 39, 1339.
          Product Information
          CAS number65646-68-6
          ATP CompetitiveN
          FormOrange solid
          Hill FormulaC₂₆H₃₃NO₂
          Chemical formulaC₂₆H₃₃NO₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetActive in the prevention and treatment of a variety of neoplasms in animals.
          Purity≥97% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSVH6420000
          Safety Information
          R PhraseR: 20/21/22-36/37/38-60-61

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          May impair fertility.
          May cause harm to the unborn child.
          S PhraseS: 26-36/37/39-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          390900

          References

          Reference overview
          Formelli, F., et al. 1996. FASEB J. 10, 1014.
          Naik, H.R., et al. 1995. Adv. Pharmacol. 33, 315.
          Delia, D., et al. 1993. Cancer Res. 53, 6036.
          Pienta, K.J., et al. 1993. Cancer Res. 53, 224.
          Grubbs, C.J., et al. 1990. Anticancer Res. 10, 661.
          McCarthy, D.J., et al. 1987. Cancer Res. 47, 5014.
          Moon, R.C., et al. 1979. Cancer Res. 39, 1339.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-March-2008 JSW
          SynonymsFenretinide, 4HPR, N-(4-Hydroxyphenyl)-all-trans Retinamide
          DescriptionA synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity. Active in the prevention and treatment of a variety of neoplasms in animals. Inhibits proliferation in cell lines of human breast cancer, prostate adenocarcinoma, and ovarian carcinoma. Inhibits angiogenesis, as well as endothelial cell motility and tubule formation. Induces apoptosis in malignant hemopoietic cell lines.
          FormOrange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number65646-68-6
          RTECSVH6420000
          Chemical formulaC₂₆H₃₃NO₂
          Structure formulaStructure formula
          Purity≥97% by TLC
          SolubilityAcetone, DMSO (25 mg/ml), or Ethanol
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 3998
          ReferencesFormelli, F., et al. 1996. FASEB J. 10, 1014.
          Naik, H.R., et al. 1995. Adv. Pharmacol. 33, 315.
          Delia, D., et al. 1993. Cancer Res. 53, 6036.
          Pienta, K.J., et al. 1993. Cancer Res. 53, 224.
          Grubbs, C.J., et al. 1990. Anticancer Res. 10, 661.
          McCarthy, D.J., et al. 1987. Cancer Res. 47, 5014.
          Moon, R.C., et al. 1979. Cancer Res. 39, 1339.