393204 4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem

393204
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₁₆O₂ 75899-68-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      393204-1MG
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          Glass bottle 1 mg
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          Description
          OverviewA major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca2+ and irreversibly inhibits Na+, K+-ATPase activity (IC50 = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).
          Catalogue Number393204
          Brand Family Calbiochem®
          SynonymsHNE, 4-Hydroxy-2-nonenal
          References
          ReferencesSoh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
          Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
          Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
          Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
          Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
          van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
          Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.
          Product Information
          CAS number75899-68-2
          ATP CompetitiveN
          FormLiquid
          FormulationSupplied at 10 mg/ml in ethanol
          Hill FormulaC₉H₁₆O₂
          Chemical formulaC₉H₁₆O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNa+, K+-ATPase activity
          Primary Target IC<sub>50</sub>120 µM against Na+, K+-ATPase activity
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSRA8510000
          Safety Information
          R PhraseR: 11

          Highly flammable.
          S PhraseS: 7-16

          Keep container tightly closed.
          Keep away from sources of ignition - No Smoking.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Flammable
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          393204

          References

          Reference overview
          Soh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
          Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
          Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
          Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
          Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
          van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
          Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-July-2008 RFH
          SynonymsHNE, 4-Hydroxy-2-nonenal
          DescriptionA major aldehydic product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca2+. Irreversibly inhibits Na+-K+-ATPase activity (IC50 = 120 µM).
          FormLiquid
          FormulationSupplied at 10 mg/ml in ethanol
          CAS number75899-68-2
          RTECSRA8510000
          Chemical formulaC₉H₁₆O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityEthanol (10 mg/ml)
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Flammable
          ReferencesSoh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
          Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
          Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
          Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
          Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
          van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
          Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.